Hypoxic Respiratory Failure in the Newborn From Origins to Clinical Management 1st Edition by Shyamala Dakshinamurti 1000442381 9781000442380

PART 1: THE ORIGINS OF HYPOXIA TOLERANCE

The Human Fetus and Metabolic Adaptations to Hypoxia

Hypoxia as a Neuroinflammatory Stimulus during Development

Human Adaptations to High Altitude

Fetal Llama Adaptation to Altitude in the Andean Altiplano

Neonates of Burrowing and Hibernating Mammals: Metabolic and Respiratory Adaptations to Hypoxia

Diving Response and Hypoxia in Deep Sea Mammals

The Phylogeny and Ontogeny of Cardiorespiratory Coupling in Vertebrates and Its Relevance to Noninvasive Monitoring of the Human Fetus

PART 2: FETAL HYPOXIA AND NEONATAL TRANSITION

Fetal and Neonatal Oxygen Environment

Fetal Oxygenation during Maternal Hypoxic Illness

Hemodynamics of the Circulatory Transition

Oxygen during Postnatal Stabilization

PART 3: BIOLOGY OF HYPOXIC RESPIRATORY FAILURE IN THE NEONATE

Hypoxia and Pulmonary Artery Structure

Animal Models of PPHN and Vasoconstrictor Signaling in Hypoxia

Hypoxia and Endothelial Dysfunction in the Lung

Effects of Hypoxia on Pulmonary Vascular Smooth Muscle Contraction and Relaxation

Cellular Oxygen Sensing, Mitochondrial Oxygen Sensing and Reactive Oxygen Species

Reactive Oxygen Species Signaling in Animal Models of Pulmonary Hypertension

Hypoxia, Myocardial Metabolic Adaptation, and Right Ventricular Performance

Hypoxic Remodeling of Neonatal Pulmonary Artery and Myocardium

Hypoxia-Induced Epigenetic Mechanisms of Pulmonary Hypertension

PART 4: HYPOXIA AND COLLATERAL DAMAGE

The Effects of Hypoxia Ischemia on the Term Brain, and a Strategic Approach

Effects of Hypoxia on Cerebral Perfusion and the Blood-Brain Barrier

Effects of Hypoxia on Airway, Alveolar Function, and Respiration

Hypoxic Respiratory Failure and the Neonatal Kidney

The Effect of Hypoxia on Intestinal Function

Effects of Hypoxia on Perinatal Drug Disposition

Anesthetic Considerations for the Neonate with Hypoxic Respiratory Failure

PART 5: DIAGNOSIS AND MANAGEMENT OF NEONATAL HYPOXIC RESPIRATORY FAILURE

Epidemiology and Outcomes of Infants with Hypoxemic Respiratory Failure

Clinical Evaluation of Hypoxic Respiratory Failure

Diagnosis of Pulmonary Hypertension by Echocardiography

Right Ventricular Performance and Ventricular Interdependence in Hypoxia

Ventilation Strategies in Neonatal Hypoxemic Respiratory Failure

Pulmonary Hypertension Phenotypes in the Newborn

Special Consideration: HRF in Congenital Diaphragmatic Hernia

Special Consideration: Hypoxemic Respiratory Failure among Patients with Hypoxic Ischemic Encephalopathy

Special Consideration: HRF in the Preterm

Hypoxemic Respiratory Failure: Neonatal Cases

Index