Firestein and Kelley s Textbook of Rheumatology 11th Edition by Gary S Firestein, Ralph Budd, Sherine Gabriel, Gary Koretzky, Iain McInnes, James O Dell ISBN 9780323639200 0323639224

Firestein and Kelley s Textbook of Rheumatology 11th Edition by Gary S Firestein, Ralph Budd, Sherine Gabriel, Gary Koretzky, Iain McInnes, James O Dell – Ebook PDF Instant Download/Delivery: 9780323639200 ,0323639224 
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ISBN 10: 0323639224 
ISBN 13: 9780323639200
Author: Gary S Firestein, Ralph Budd, Sherine Gabriel, Gary Koretzky, Iain McInnes, James O Dell

• Abarca desde la ciencia básica, la inmunología, la anatomía y la fisiología, hasta las pruebas diagnósticas, los procedimientos y los procesos patológicos específicos, e incluye datos clave sobre resultados terapéuticos para tomar decisiones clínicas bien documentadas.
• Incorpora capítulos nuevos: «Células linfoides innatas y linfocitos citolíticos naturales», «Patogenia de las enfermedades mediadas por inflamasomas», «Bisfosfonatos», «Ecografía en reumatología» y «Evaluación de la artritis monoarticular y poliarticular».
• Incluye 1.200 ilustraciones de alta calidad, tablas de referencia rápida y fotografías clínicas en color.
• Comparte el conocimiento y la experiencia de científicos de renombre internacional, entre los que se incluye un nuevo editor, el Dr. Gary A. Koretzky, especialista en inmunología y reumatología.
• Permite la revisión de los avances en las ciencias básicas y sus aplicaciones clínicas, y constituye una guía fiable basada en la evidencia de todas las enfermedades y los síndromes reumatológicos.
• Incluye el acceso a la versión electrónica en inglés, que permite consultar el texto completo, las figuras y las referencias bibliográficas de la obra desde diversos dispositivos

Firestein and Kelley s Textbook of Rheumatology 11th Edition Table of contents:

Part 1. Structure and Function of Bone, Joints, and Connective Tissue

1. Biology of the Normal Joint

Classification of Joints

Developmental Biology of the Diarthrodial Joint

Interzone Formation and Joint Cavitation

Cartilage Formation and Endochondral Ossification

Development of Articular Cartilage

Development of the Joint Capsule, Synovial Lining, Menisci, and Intracapsular Ligaments

Development of Nonarticular Joints

Organization and Physiology of the Mature Joint

Synovium

Joint Innervation

Synovial Fluid and Nutrition of Joint Structures

Generation and Clearance of Synovial Fluid

Synovial Fluid as an Indicator of Joint Function

Lubrication and Nutrition of the Articular Cartilage

Mature Articular Cartilage

Subchondral Bone

Tendons

Ligaments

Bursae

Menisci

Conclusion

2. Synovium

Structure

Function

Conclusion

3. Cartilage and Chondrocytes

Introduction

Cartilage Structure

Structure-Function Relationships of Cartilage Matrix Components

Morphology, Classification, and Normal Function of Chondrocytes

Interactions of Chondrocytes With the Extra-cellular Matrix

Angiogenic and Antiangiogenic Factors

Roles of Growth and Differentiation (Anabolic) Factors in Normal Cartilage Metabolism

Epigenetic Regulation of Cartilage Homeostasis

Role of the Chondrocyte in Cartilage Pathology

Conclusion

4. Biology, Physiology, and Morphology of Bone

Structure and Composition of Bone

Conclusion

5. Muscle: Anatomy, Physiology, and Biochemistry

Introduction

Structure

Events During Muscle Contraction

Transmission of Force to the Exterior

Energetics

Fatigue and Recovery

Plasticity

Aging

Conclusion

6. Biomechanics

Introduction

Kinematics

Kinetics

Joint Biomechanics

Joint Constraint and Stability

Mechanical Loading on Tendon

7. Regenerative Medicine and Tissue Engineering

Introduction

Intrinsic Repair

Emerging Clinical Applications Targeting Endogenous Repair

Extrinsic Repair: Current Therapeutic Interventions

Regenerative Medicine and Tissue Engineering in Arthritis

Conclusion

8. Proteinases and Matrix Degradation

Introduction

Extra-cellular Matrix-Degrading Proteinases

Regulation of Proteinase Activity

Inhibition of Proteinases by Endogenous Inhibitors

Part 2. Cells Involved in Autoimmune Diseases and Inflammation

9. Dendritic Cells

Introduction

Dendritic Cell Subsets and Development

New Developments in Dendritic Cell Classification

Impairment of Dendritic Cell Biology in Disease

Immunotherapeutic Strategies and Clinical Trials

Future Directions

10. Mononuclear Phagocytes

Introduction

Steady-State Development of Synovial Macrophages

Transcriptional Regulation of Synovial Macrophages

Synovial Macrophage Production of Cytokines and Chemokines

Conclusion

11. Neutrophils

Overview

Neutrophil Development, Morphology, and Content

Neutrophil Activation and Signal Transduction

Neutrophil Function

Heritable Disorders of Neutrophil Function

Neutrophil Relevance to Rheumatic Disease

Conclusion

12. T Lymphocytes

Introduction

T Cell Development

Peripheral Migration and Homeostatic Proliferation of T Cells

T Cell Subsets

Future Directions

13. B Cells

Introduction

Immunoglobulins: Structure and Function

B Cell Development

Sites of B Cell Homing and Activation

B Cell Activation and Differentiation

Repertoire Selection

B Cell–Mediated Autoimmunity

Conclusion

14. Fibroblasts and Fibroblast-like Synoviocytes

What Is a Fibroblast?

Physiologic Characteristics and Functions of Fibroblasts

Fibroblasts in Rheumatic Diseases

Fibroblast-like Synoviocytes in Rheumatoid Arthritis

Conclusion

15. Mast Cells

Introduction

Basic Biology of Mast Cells

Role of Mast Cells in Health and Disease

Conclusions

16. Innate Lymphoid Cells and Natural Killer Cells

Introduction

Biology of ILCs and NK Cells

ILCs and Potential Contributions to Rheumatologic Disease

Summary

17. Platelets and Megakaryocytes

Introduction

Platelet Structure

Platelet Production

Platelets and Hemostasis

Signaling Pathways in Platelet Activation

The Platelet as an Inflammatory Cell

The Megakaryocyte as an Inflammatory Cell

Platelets, Megakaryocytes, and Rheumatic Diseases

Conclusion

Part 3. Effector Mechanisms in Autoimmunity and Inflammation

18. Principles of Signaling

Introduction

Receptors With Enzymatic Activity

Receptors That Recruit Molecules With Enzymatic Activity

Innate Receptor Signaling

Intra-cellular Receptor Signaling

Adaptor Molecules

Signaling Pathways

Transcription Factors

Conclusion

19. The Immunologic Repercussions of Cell Death

Introduction

Types of Cell Death

Molecular Mechanisms of Caspase Activation

Molecular Pathways of Regulated Necrosis

Cell Death and Immunity

Conclusion and Clinical Potential

20. Innate Immunity

Introduction

Evolutionary Origins of Innate Immunity

Pathogen Recognition by the Innate Immune System

PAMPs and DAMPs: Patterns for Innate Immune Recognition

Effector Mechanisms of Innate Immune Responses

Cell Types Mediating Innate Immunity

Influence of Innate Mechanisms on Adaptive Immunity

Disease Associations Involving Innate Immunity

Future Directions

Connection to the Clinic

21. Adaptive Immunity

Introduction

Phylogenetic Appearance of the Adaptive Immune System

Cardinal Features of the Adaptive Immune System

Cells of the Adaptive Immune System

Development of Adaptive Immune Cells

Anatomic Organization of the Peripheral Adaptive Immune System

Trafficking of Adaptive Immune Cells

Cell-to-Cell Interactions That Support Development of an Immune Response

Consequences of Failed Development or Activation of the Adaptive Immune System

Conclusion

22. Autoimmunity and Tolerance

Introduction

Definition and Classification of Pathogenic Autoimmunity

Animal Models of Autoimmunity

Tolerance Mechanisms

Theories of Autoimmunity

Immunologic Mechanisms of Tissue Inflammation and Dysfunction

Pathophysiology of Autoimmune Rheumatic Diseases

Genetics of Autoimmune Diseases

Sex and Autoimmunity

Microbial and Other Environmental Triggers

Conclusion

23. The Microbiome in Health and Disease

The Human Microbiome

What Is the Microbiome?

Principles of Host-Microbiome Interaction

What Affects the Microbiome?

How Is the Microbiome Determined From a Sample?

How Are Microbiome Data Interpreted?

What Can the Microbiome Be Used for Today?

What Microbiome Principles From Other Areas of Medicine or Biology Can Be Applied to Rheumatology?

How Will the Microbiome Be Useful to Rheumatologists in the Future?

24. Metabolic Regulation of Immunity

Introduction

Metabolic Rewiring in Innate Immunity

Metabolic Rewiring in Adaptive Immunity

Mitochondria and Immunity

Metabolic Interplay in the Immune Microenvironment

Conclusion

25. Genetics of Rheumatic Diseases

Introduction

Evidence for a Genetic Component to Rheumatic Diseases

Study Design

Identification of High-Risk Groups

26. Epigenetics of Rheumatic Diseases

Introduction

Epigenetic Regulation

Epigenetics and the Immune Response

Challenges Faced in Translational Epigenetics Research

Epigenetics in Rheumatic Diseases

Epigenetic Modifications as Biomarkers of Rheumatic Disease

Future Directions

27. Complement System

Introduction

Functions of the Complement System

Terminology Used to Describe Complement and Its Activation Fragments

Activation Pathways

Regulation of Complement Activation

Receptors for Complement Fragments

Functions of the Complement System

Complement Deficiency

Targeted Complement Therapeutics

Complement in Rheumatic Diseases

Conclusion

28. Prostaglandins, Leukotrienes, and Related Compounds

Introduction

Biosynthesis of Eicosanoids

Products of the Cyclooxygenase Pathway

Eicosanoid Receptors

Platelet-Activating Factor

Eicosanoids as Regulators of Inflammation and Immune Responses

Modulation of Eicosanoid Synthesis by Administration of Precursor Fatty Acids

29. Chemokines and Cellular Recruitment

Introduction

Defining Membership of the Chemokine Family

The Chemokine Nomenclature System

The Inflammatory and Homeostatic Chemokine Model

The Chemokine Receptor Family

Atypical Chemokine Receptors

Chemokines in an Evolutionary Context

How Chemokines Attract Cells to Particular In Vivo Destinations

Chemokines and Their Receptors in Disease

Conclusion

30. Angiogenesis

Introduction

Endothelial Cells

31. Cytokines

Introduction

Classification of Cytokines

Assessing Cytokine Function In Vitro and In Vivo

Cytokine Receptors

Regulation of Cytokine Expression

Effector Function of Cytokines

Cytokine Effects Beyond Immune Regulation

Conclusion

32. Experimental Models for Rheumatoid Arthritis

Introduction

Arthritis Caused by Infectious Agents

Arthritis Caused by Bacterial Fragments

Adjuvant-Induced Arthritis

Cartilage Protein-Induced Arthritis

Spontaneous Arthritis

Use of Animal Models

Ethical Considerations

Conclusion

33. Neuronal Regulation of Pain and Inflammation

Introduction

Primary Afferent Fibers

Efferent Functions of Primary Afferent Fibers

Neuronal Regulation of Inflammation in Acute Inflammatory Models

Neuronal Regulation of Inflammation in Chronic Models of Inflammation

Sympathetic Effects on Peripheral Inflammation Are Time Dependent

Parasympathetic Effects on Peripheral Inflammation

Role of Pain in Inflammatory Disease

Part 4. Broad Issues in the Approach to Rheumatic Disease

34. Clinical Research Methods in Rheumatic Disease

Introduction

Measures of Disease Occurrence

Measures of Effect

Data Sources for Research in Rheumatology

Clinical Research Study Designs

Biases in Study Design

Effect Measure Modification

Screening

Conclusion

35. Economic Impact of Arthritis and Rheumatic Conditions

Introduction

Cost-of-Illness Studies of Arthritis and the Rheumatic Conditions

Summary

36. Assessment of Health Outcomes

Introduction

Health Outcome Assessments

What Needs to Be Measured: Defining Measurement Needs

Outcome Measures in Arthritis

Deciding on an Instrument for a Health Outcome Assessment

Examples of Arthritis Instruments

Areas of Growth in Health Outcome Assessment

Conclusion

37. Biomarkers in Rheumatology

Biomarker Definitions and Applications

Defining Patient Heterogeneity

Pitfalls in Translation From Biomarker Discovery to Clinical Utility

Surrogate Biomarkers

Companion Diagnostics Versus CLIA Regulatory Routes

Safety Biomarkers

Biomarkers in Rheumatic Diseases

Biomarkers in Osteoarthritis

Biomarkers in Rheumatoid Arthritis

Biomarkers in Systemic Lupus Erythematosus

Next Horizons for Biomarkers

38. Occupational and Recreational Musculoskeletal Disorders

Introduction

Occupation-Related Musculoskeletal Disorders

Occupation-Related Rheumatic Diseases

Recreation- and Sports-Related Musculoskeletal Disorders

Performing Arts–Related Musculoskeletal Disorders

39. Cardiovascular Risk in Inflammatory Rheumatic Disease

Introduction

Biologic Mechanisms: Relationship Between Inflammation and Cardiovascular Disease

Cardiovascular Morbidity and Mortality in Rheumatoid Arthritis and Systemic Lupus Erythematosus

Risk Factors for Cardiovascular Disease

Cardiovascular Mortality, Morbidity, and Risk Factors in Other Rheumatic Diseases

Managing Cardiovascular Risk in Rheumatic Disease

Cardiovascular Disease Risk Assessment

Conclusion

40. Cancer Risk in Rheumatic Diseases

Introduction

Malignancy in Autoimmune Rheumatic Diseases

Rheumatoid Arthritis

Systemic Lupus Erythematosus

Systemic Sclerosis (Scleroderma)

Idiopathic Inflammatory Myopathy

Sjögren Syndrome

Vasculitis

Seronegative Spondyloarthritis

Cancer Risks Associated With Anti-rheumatic Drug Therapies

Nonbiologic DMARD Therapy

Biologic Response Modifiers

Cancer Screening in Patients With Rheumatic Disease

Conclusion

41. Introduction to Physical Medicine and Rehabilitation

Introduction

Rehabilitation Interventions

Specific Disorders

Alternative, Innovative, and Emerging Therapeutic Approaches

Conclusion

42. Pregnancy and Rheumatic Diseases

Introduction

Interplay of Rheumatic Disease and Pregnancy Physiology

General Principles of Pregnancy and Rheumatic Disease: Pre-pregnancy Assessment

Systemic Lupus Erythematosus

Overlap Syndromes and Undifferentiated Connective Tissue Disease

Sjögren’s Syndrome

Antiphospholipid Antibody

Inflammatory Arthritis

Inflammatory Myositis

Systemic Sclerosis

Vasculitis

Medications During Pregnancy and Breastfeeding

Paternal Medication Use

Pregnancy-Related Issues for Rheumatic Disease Patients

Conclusion

Part 5. Evaluation of Generalized and Localized Symptoms

43. History and Physical Examination of the Musculoskeletal System

History in a Patient With Musculoskeletal Disease

Systematic Method of Examination

Recording the Joint Examination

Interpreting the Joint Examination

Examination of Specific Joints

44. Ultrasound in Rheumatology

Introduction

Technical Aspects

Artifacts

Examination Technique

Ultrasound in Rheumatology Definitions

Rheumatoid Arthritis

Osteoarthritis

Crystalline Arthropathy

Gout

Calcium Pyrophosphate Dihydrate Crystal Deposition

Spondyloarthropathy

Polymyalgia Rheumatica

Giant Cell Arteritis

Sjögren’s Syndrome

Sclerosing Diseases

Non-inflammatory Conditions

Pediatric Rheumatology

Ultrasound in Rheumatology Intervention

Conclusion

45. Evaluation of Monoarticular and Polyarticular Arthritis

Introduction

Approach to the Patient With Arthritis

Synovial or Bone Biopsy

Differential Diagnosis

Formal Criteria and Their Role in Clinical Diagnosis

Preliminary Diagnoses, Working Diagnoses, Presumptive Treatments, Reassessments, and Future Perspectives

46. Skin and Rheumatic Diseases

Diagnosis of Skin Lesions Associated With Rheumatic Diseases

Psoriasis

Reactive Arthritis

Rheumatoid Arthritis

Juvenile Rheumatoid Arthritis/Still’s Disease

Lupus Erythematosus

Neonatal Lupus Syndrome

Sjögren’s Syndrome

Dermatomyositis

Morphea, Systemic Sclerosis, and Other Sclerosing Conditions

Primary Vasculitis Involving the Skin

Infections

Panniculitis

Relapsing Polychondritis

Infiltrative Diseases

Miscellaneous Skin Diseases and Arthritis

47. The Eye and Rheumatic Diseases

Introduction

Ocular Anatomy and Physiology

Ocular Immune Response

Uveitis

Scleritis and Corneal Melt

Orbital Disease

Optic Neuritis

Medication-Related Ocular Toxicity

Conclusion

Part 6. Differential Diagnosis of Regional and Diffuse Musculoskeletal Pain

48. Neck Pain

Epidemiology

Anatomy

Axial Neck Pain

Radiculopathy and Myelopathy

Clinical Features

Diagnostic Evaluation

Differential Diagnosis and Treatment

49. Shoulder Pain

Introduction

Anatomy and Function

Diagnosis

Intrinsic Factors Causing Shoulder Pain

Extrinsic or Regional Factors Causing Shoulder Pain

50. Low Back Pain

Epidemiology

Anatomy

Clinical Evaluation

Differential Diagnosis

Spondylolisthesis

Spinal Stenosis

Diffuse Idiopathic Skeletal Hyperostosis

Treatment

Outcome

Conclusion

51. Hip and Knee Pain

Introduction

Knee Pain

Hip Pain

52. Foot and Ankle Pain

Introduction

Functional Anatomy and Biomechanics

Diagnostic Evaluation

Imaging

Differential Diagnosis of Ankle Pain

Differential Diagnosis of Foot Pain

Nonoperative Treatment

Operative Treatment

Conclusion

53. Hand and Wrist Pain

Introduction

Patient Evaluation

Physical Examination

Common Causes of Hand and Wrist Pain

54. Temporomandibular Joint Pain

Introduction

Arthritis of the Temporomandibular Joint

Internal Derangements

Neoplasms

Myofascial Pain and Dysfunction

Conclusion

55. Fibromyalgia

Introduction

Historical Perspective

Diagnostic Criteria

Epidemiology

Clinical Features

Differential Diagnosis and Comorbidities

Assessment of Severity

Mechanisms of Disease

Social and Psychological Factors

Treatment Approaches

Outcome

Part 7. Diagnostic Tests and Procedures in Rheumatic Diseases

56. Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology

Introduction

Synovial Fluid Analysis

Biochemical Analysis of Synovial Fluid

Synovial Biopsy

Synovial Pathology

Synovial Immunohistology

Conclusion

57. Arthrocentesis and Injection of Joints and Soft Tissues

Introduction

Indications, Contraindications, and Potential Complications of Arthrocentesis and Soft Tissue Injections

Drugs and Preparations Used for Injection

Procedures Description

Upper Limb Injections

Lower Limbs Injections

Soft Tissue Injections: Upper Limbs

Soft Tissue Injections: Lower Limbs

Conclusion

58. Anti-nuclear Antibodies

Introduction

History

Relevance of Anti-nuclear Antibodies to Disease Pathogenesis

Methods of Detection

Interpretation of the FANA

Diseases Associated With Anti-nuclear Antibodies

Clinical Utility of Anti-nuclear Antibody Testing

59. Autoantibodies in Rheumatoid Arthritis

Introduction

Citrullination-Associated Autoantibodies

Antibodies to Citrullinated Proteins

Anti-citrullinated Protein Autoantibodies (ACPA)

Antibodies to Peptidylarginine Deiminase Enzymes

The Etiology and Pathogenesis of Citrullination-Associated Autoantibodies

Origin and Pathogenesis of Citrullination-Associated Antibodies

Mechanisms for Citrullination-Associated Autoantigen Production in the Rheumatoid Joint

Antibodies to Chemically Modified Antigens

Nonspecific Rheumatoid Arthritis Autoantibodies

Conclusion

60. Acute Phase Reactants

Introduction

Acute Phase Response

Acute Phase Reactants in the Management of Rheumatic Diseases

Practical Use of Acute Phase Reactants

C-Reactive Protein and Health: Associations with Nonrheumatologic Conditions

61. Imaging in Rheumatic Diseases

Introduction

Radiography

Computed Tomography

Magnetic Resonance Imaging

Other Imaging Modalities

Conclusion

Part 8. Pharmacology of Anti-rheumatic Drugs

62. Therapeutic Targeting of Prostanoids

Introduction

History

Mechanism of Action

Pharmacology and Dosing

Therapeutic Effects

Adverse Effects

Effects of Concomitant Drugs, Diseases, and Aging

Choosing Anti-inflammatory Analgesic Therapy

Conclusion

63. Glucocorticoid Therapy

Introduction

Characteristics of Glucocorticoids

Genomic and Nongenomic Modes of Action

Glucocorticoid Effects on Hypothalamic-Pituitary-Adrenal Axis

Glucocorticoid Effects on the Immune System

Pharmacology and Clinical Considerations

Glucocorticoid Therapy

Adverse Effects and Monitoring

Future Directions

64. Traditional DMARDs: Methotrexate, Leflunomide, Sulfasalazine, Hydroxychloroquine, and Combination Therapies

Methotrexate

Leflunomide

Anti-malarials

Combination DMARD Therapy in Rheumatoid Arthritis

65. Immunosuppressive Drugs

Introduction

Cyclophosphamide

Azathioprine

Mycophenolate Mofetil

Cyclosporine and Tacrolimus

Conclusion

66. Anti-cytokine Therapies

Introduction

Tumor Necrosis Factor

Interleukin-1

Interleukin-6

Interleukin-12/23

Interleukin-17

Dual Cytokine Inhibition

JAK-STAT Pathway

Monitoring When Treating With Cytokine Blockade

Pregnancy and Breastfeeding

Vaccinations

Conclusion

67. Cell-Targeted Biologics and Emerging Targets: Rituximab, Abatacept, and Other Biologics

Introduction

Targeting B Cells

Targeting Co-stimulatory Molecules

Targeting T Cells

Conclusion

68. Intra-cellular Targeting Agents in Rheumatic Disease

Introduction

Signal Transduction Pathways

p38 MAPK Inhibitors

MEK Inhibitors

Spleen Tyrosine Kinase Inhibitors

Janus Kinase Inhibitors

BTK Inhibitors

PI3K Inhibitors

Sphingosine-1-Phosphate Modulators

Phosphodiesterase Inhibitors

Conclusion

69. Urate-Lowering Therapy

Introduction

Nonpharmacologic Treatment of Hyperuricemia

Xanthine Oxidase Inhibition

Febuxostat

Uricosurics

Uricases

Future Directions

70. Bisphosphonates

Introduction

Clinical Pharmacology

Chemistry of Bisphosphonates

Pharmacokinetics

Treatment Effects and Indications

71. Analgesic Agents in Rheumatic Disease

Introduction

Physiology of Pain Perception (the “Pain Experience”)

Pain Classification

Pharmacologic Treatment of Chronic Pain

Opioids

Anti-depressants

Anti-convulsants

Muscle Relaxants

Emerging Targets

72. Nutrition and Rheumatic Diseases

Introduction

Nutrition and Inflammation

Specialized Proresolving Mediators and N-3 Fatty Acids

Nutrition in the Etiology of Rheumatic Diseases

Nutrition in the Management of Rheumatic Diseases

Conclusion

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