Advanced Drug Delivery Systems in the Management of Cancer 1st edition by Kamal Dua, Meenu Mehta, Terezinha de Jesus Andreoli Pinto 9780323900799 0323900798

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ISBN 10: 0323900798
ISBN 13: 9780323900799 
Author:  Kamal Dua PhD, Meenu Mehta, Terezinha de Jesus Andreoli Pinto , Lisa G. Pont, Kylie A. Williams

Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index.

This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations.

Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer.

• Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer
• Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers
• Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems

Advanced Drug Delivery Systems in the Management of Cancer 1st Table of contents:

Chapter 1: Introduction to Cancer Cell Biology
1.1 Abstract
1.2 Introduction
1.3 Types of Cancer
1.4 Pathophysiology of Cancer

Chapter 2: Current Practice in Cancer Pharmacotherapy
2.1 Abstract
2.2 Introduction
2.3 Conclusions

Chapter 3: Current Practices in Oncology Drug Delivery
3.1 Abstract
3.2 Introduction
3.3 Past Therapeutic Approaches in Cancer (1900 and Earlier)
3.4 Current Approaches of Drug Delivery
3.5 Future Directions

Chapter 4: Emerging Need of Advanced Drug Delivery Systems in Cancer
4.1 Abstract
4.2 Introduction
4.3 Multidrug Resistance in Cancer Cells
4.4 Toxic Effects of Chemotherapy
4.5 Hazardous Effects of Radiation Oncology
4.6 Polypharmacology in Anticancer Therapy
4.7 Advanced Drug Delivery Systems
4.8 Stimuli-Responsive Drug Delivery Systems
4.9 Conclusion and Future Perspectives

Chapter 5: Target Drug Delivery in Cancer
5.1 Abstract
5.2 Introduction
5.3 Ligand-Mediated Targeting (Surface Modification)
5.4 Protein-Mediated Targeting
5.5 Carbohydrate-Mediated Drug Delivery
5.6 Physical Targeting via EPR Effects
5.7 Triggered Targeting
5.8 Concluding Remarks

Chapter 6: Material and Strategies Used in Oncology Drug Delivery
6.1 Abstract
6.2 Introduction
6.3 Materials and Stratagem Applied in Cancer Therapy
6.4 Targeted Delivery: Mechanistic Pathway
6.5 Future Challenges in Cancer Therapy
6.6 Conclusions

Chapter 7: Hydrogel-Based Drug Delivery Systems for Cancer Therapy
7.1 Abstract
7.2 Introduction
7.3 Hydrogels: An Overview
7.4 Hydrogel-Based Drug Delivery Systems for Cancer Therapy
7.5 Marketed/Patented Hydrogel-Based Drug Delivery Systems
7.6 Conclusions and Future Perspectives

Chapter 8: Recent Advances in Drug Formulation Development for Targeting Lung Cancer
8.1 Acknowledgments
8.2 Introduction
8.3 Immunotherapy: Biomolecules Targeting Lung Cancer
8.4 Lung Cancer Therapy via Inhalation
8.5 Treatment of Metastatic Lung Cancer
8.6 The Mechanism of Drug Resistance in Lung Cancer and Its Associated Treatments
8.7 Conclusions

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