BASIC CONCEPTS IN MEDICINAL CHEMISTRY 3rd Edition by Marc Harrold, Robin Zavod ISBN 158528694X 9781585286942

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ISBN 10: 158528694X
ISBN 13: 9781585286942
Author: Marc Harrold, Robin Zavod

Designed to help students incrementally build their knowledge of fundamental concepts of medicinal chemistry and their applications to therapeutic decisions, it is progressively organized. Specific sections of the text have been updated to make potentially confusing concepts easier to understand. Numerous examples and review questions further reinforce learning and analytical skills.

This updated and expanded edition of the popular textbook, Basic Concepts in Medicinal Chemistry, has been enhanced with new subject material, numerous self-assessment tools, and special features to advance and strengthen the learning process.

New in the Third Edition

• Enhanced explanations, discussions, and examples in many key chapters
• Additional summary tables to help readers better select the proper drug binding interaction
• Expanded discussion on Pharmacogenomics, including multiple specific examples
• Updated examples throughout the text to include a wider range of drugs and drug classes
• Increased focus on application of concepts to therapeutic decisions and pharmacy practice

BASIC CONCEPTS IN MEDICINAL CHEMISTRY 3rd Edition Table of contents:

PART I: Introduction to Medicinal Chemistry

1. Overview of Medicinal Chemistry

   • Definition and Scope of Medicinal Chemistry
   • Historical Perspective and Development of Modern Medicinal Chemistry
   • The Role of Medicinal Chemistry in Drug Discovery and Development

2. Basic Principles of Drug Action

   • Pharmacodynamics: How Drugs Work in the Body
   • Pharmacokinetics: The Journey of Drugs through the Body
   • Drug Receptors and Their Mechanisms of Action

3. The Drug Discovery Process

   • From Concept to Clinic: The Journey of a Drug
   • Target Identification and Validation
   • High-Throughput Screening and Lead Optimization

PART II: Chemical Principles and Drug Design

4. Structure-Activity Relationships (SAR)

   • Introduction to SAR and Its Role in Medicinal Chemistry
   • Chemical Modifications and Their Impact on Biological Activity
   • Case Studies in SAR of Common Drug Classes

5. Chemical Bonding and Molecular Interactions

   • Types of Chemical Bonds and Their Relevance to Drug Design
   • Molecular Interactions: Hydrogen Bonds, Ionic Interactions, and Van der Waals Forces
   • The Role of Lipophilicity and Polarity in Drug Design

6. Pharmacophore and Drug Design

   • Defining the Pharmacophore
   • Designing Drugs Based on the Pharmacophore Concept
   • Computational Approaches in Drug Design

PART III: Classes of Drugs and Their Mechanisms

7. Antimicrobial Agents

   • Classification of Antimicrobials: Antibiotics, Antivirals, and Antifungals
   • Mechanisms of Action of Common Antimicrobial Agents
   • Resistance and the Future of Antimicrobial Drug Development

8. Chemotherapy and Cancer Drugs

   • The Mechanisms of Action of Cancer Therapeutics
   • Alkylating Agents, Antimetabolites, and Targeted Therapies
   • Drug Resistance in Cancer and the Development of New Chemotherapies

9. Central Nervous System (CNS) Drugs

   • Neurotransmitters and Their Receptors
   • Types of CNS Drugs: Antidepressants, Antipsychotics, and Antianxiety Medications
   • Challenges in Designing Drugs for CNS Disorders

10. Cardiovascular Drugs

    • Hypertension, Arrhythmias, and Heart Failure
    • Mechanisms of Action for Antihypertensive and Antiarrhythmic Drugs
    • Designing Drugs for Cardiovascular Disorders

11. Endocrine and Hormonal Drugs

    • The Role of Hormones in Disease and Treatment
    • Drugs for Diabetes, Thyroid Disorders, and Reproductive Health
    • Advances in Hormonal Therapies

PART IV: Drug Metabolism and Toxicology

12. Drug Metabolism and Biotransformation

    • Introduction to Phase I and Phase II Metabolism
    • Cytochrome P450 Enzymes and Their Role in Drug Metabolism
    • The Impact of Metabolism on Drug Efficacy and Toxicity

13. Toxicology and Drug Safety

    • Types of Drug Toxicity and Mechanisms of Action
    • The Importance of Preclinical and Clinical Toxicology Studies
    • Regulatory Guidelines for Drug Safety

14. Drug Formulation and Delivery

    • Types of Drug Formulations: Tablets, Injectables, and Topicals
    • Drug Delivery Systems: Controlled Release and Nanomedicine
    • The Role of Medicinal Chemistry in Drug Formulation

PART V: Current Trends and Future Directions

15. Biotechnology and Biologics

    • The Rise of Biologic Drugs: Monoclonal Antibodies, Vaccines, and Gene Therapy
    • Challenges in Designing Biologic Therapeutics
    • The Future of Biotech Drugs and Personalized Medicine

16. The Role of Medicinal Chemistry in Drug Resistance

    • Mechanisms of Drug Resistance in Infectious Diseases and Cancer
    • Approaches to Overcoming Drug Resistance
    • The Role of Medicinal Chemists in Combating Resistance

17. Future Trends in Medicinal Chemistry

    • Advances in Computational Chemistry and Artificial Intelligence in Drug Design
    • Targeting the “Undruggable” Proteins
    • The Role of Medicinal Chemistry in the Development of Next-Generation Therapies

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