Cellular Senescence in Disease 1st Edition by Manuel Serrano, Daniel Munoz Espin ISBN 9780128225141 0128225149

Cellular Senescence in Disease 1st Edition by Manuel Serrano, Daniel Munoz Espin – Ebook PDF Instant Download/Delivery: 9780128225141 ,0128225149
Full download Cellular Senescence in Disease 1st Edition after payment

Product details:

ISBN 10: 0128225149
ISBN 13: 9780128225141
Author: Manuel Serrano, Daniel Munoz Espin

Research in the field of senescence has boomed recently due to the gradual realization that senescent cells are associated with a significant number of diseases. The genetic or pharmacological elimination of senescent cells can cause widespread benefits and improves outcomes for most of those diseases. Cellular Senescence in Diseases presents an updated review of the role of cellular senescence in multiple pathologies. Focus is given to those diseases where the implication of senescence has been more extensively documented, such as (cancer, lung and liver diseases, diabetes, Neurodegenerative diseases and others).

The Editors recruited a group of worldwide experts in each individual pathology to review the role of cellular senescence in each one of them, aiming at identifying potential therapeutic pathways. The first two chapters provide an overview of the cellular senescence principles. Next, the chapters are divided into specific diseases. Cancer, including premalignant lesions (OIS), Advanced disease (TIS), and Metastasis are covered. The following condition covered is Lund diseases, including IPF, COPD, and Pulmonary Hypertension. Next Liver Diseases are covered, including Fibrosis and Cirrhosis, and Fatty liver disease. Next there is coverage for Kidney implications, including fibrosis and transplantation. Vascular diseases are covered next including infarction and hear fibrosis, and atherosclerosis. Both diabetes types 1 and 2 are covered next. Following chapters cover Obesity, Sarcopenia, and Bone and Cartilage disorders, respectively. Neurodegenerative diseases are covered next, focusing on Alzheimer and Parkinson. The next chapter discusses accumulation of senescent cell in tissues during aging. The two final chapters cover current developments and conclusions.

Cellular Senescence in Diseases is designed for researchers and clinicians with a focus on the cellular mechanisms of diseases.  All chapters cover current experimental therapeutic approaches to eliminate or cancel the pathological effects of senescent cells.  Pharmaceutical scientists may also benefit from the contents of the book in the exploration of novel therapeutic opportunities.

• 2023 PROSE Awards – Winner: Category: Biomedicine and Neuroscience: Association of American Publishers
• Provides a thorough introduction to Cellular Senescence
• Covers all major pathologies for which cellular senescence has shown evidence of involvement
• Focuses on possible therapeutic pathways
• Edited and authored by worldwide experts

Cellular Senescence in Disease 1st Edition Table of contents:

Part 1. Fundamentals

Chapter 1. Cellular senescence: from old to new testament

Old testament—genesis of senescence

New testament—from mechanisms and roles of senescence to therapies

Part 2. Cellular senescence in disease states

Chapter 2. Premalignant lesions and cellular senescence

Introduction

Cellular senescence in premalignant lesions: evidence in various organs

Future perspectives

Chapter 3. Lung aging and senescence in health and disease

Introduction

Normal lung development and aging

A brief introduction to COPD and IPF

Abnormal hallmarks of lung aging in COPD and IPF

Future treatment targeting lung senescence

Conclusions

Supported

Abbreviations

Chapter 4. Cell senescence in pulmonary hypertension

Introduction

Pulmonary hypertension, a non-aging-related proliferative vascular disorder at the crossroads of vascular disease and cancer

General considerations about aging of the systemic and pulmonary vascular systems

Considerations about constitutive cells of pulmonary vessels and the specificity of the pulmonary vasculature

Potential mechanisms accounting for cell senescence in PH and PAH

Role for senescent cells in PH and PAH

Conclusion

Chapter 5. Liver diseases fibrosis and cirrhosis

Liver structure and function

Cellular senescence

Liver diseases—epidemiology and clinical aspects

Senescence during aging of the healthy liver

Senescence in acute liver injury

Senescence in chronic liver disease

Role of senescence in hepatic dysfunction

Evolutionary role of senescence in the liver

Senescence during hepatic carcinogenesis

Summary and closing comments

Chapter 6. Cellular senescence during aging and chronic liver diseases: mechanisms and therapeutic opportunities

Introduction

Cellular senescence in the liver

Mechanisms contributing to cellular senescence in liver

Therapies: senolytic and senostatic drugs

Conclusions and outstanding questions

List of abbreviations

Chapter 7. Kidney diseases: fibrosis

Introduction

Fibrosis is a common feature of unresolved kidney damage and kidney aging

Glomerulosclerosis, vascular sclerosis, tubulointerstitial fibrosis

ECM in renal homeostasis, injury, and repair

Cellular senescence in renal aging, AKI, and CKD

Different forms and different timing of cell-cycle arrest may have detrimental or beneficial effects in AKI and CKD

TIF and cellular senescence

Senescence and the cellular origin of TIF

Senescence-associated secretory phenotype

Transforming growth factor-β (TGF-β)

WNT/β-catenin signaling

The renin-angiotensin system (RAS)

The antiaging factor Klotho

Inflammation, innate immunity, and TIF

Senescence and TIF—physiology and pathology

Chapter 8. Kidney diseases: transplantation

Introduction

Factors determining donor organ quality and their association with senescence

Impact of cellular senescence on transplant-related injuries and transplant outcome

Rejuvenating and protecting kidney transplants

Chapter 9. Vascular diseases: atherosclerosis and atherosclerotic cardiovascular diseases

Introduction—“a man is as old as his arteries”

Features of cellular senescence in vascular cells

Evidence of cellular senescence in atherosclerosis

Factors involved in vascular senescence associated with the pathophysiology of atherosclerosis

Therapeutics targeting cellular senescence for atherosclerosis

Conclusions (limitations and perspectives)

Chapter 10. Diabetes: senescence in type 1 diabetes

Introduction

Senescent beta cell accumulation as a novel pathogenic mechanism in T1D

Outstanding questions and future directions

Conclusions and outlook

Chapter 11. Senescence in obesity: causes and consequences

Introduction

Adipose tissue function in obesity

Senescent cells accumulate in multiple tissues in obesity

Causes of cellular senescence in obesity

Threshold theory of senescent cell burden

Implications of senescence in obesity: downstream effects

Strategies to target obesity-related senescent cells

Chapter 12. A framework for addressing senescent cell burden in the osteoarthritic knee: therapeutics, immune signaling, and the local-systemic interface

Introduction

Main

Conclusion

Competing interests

Chapter 13. Osteoporosis and bone loss

Osteoporosis as a public health problem

The hallmarks of aging in bone

The role of cellular senescence in mediating age-related bone loss

Estrogen deficiency and cellular senescence

The role of cellular senescence in the effects of diabetes mellitus on bone

Cellular senescence and radiation- and chemotherapy-induced bone loss

Role of cellular senescence in the growth plate and regulation by parathyroid hormone–related peptide (PTHrP)

Summary and conclusions

Chapter 14. Cellular senescence in neurodegenerative diseases

Cellular senescence: driving force or beneficial response in neurodegeneration?

Postmitotic senescence in brain aging and neurodegenerative diseases

Replicative senescence in brain aging and neurodegenerative diseases

Demyelination, oligodendrocyte lineages, and Aβ plaque propagation in AD brains

Senolytics as AD therapy

Combination therapy for AD using senolytics and senomorphics

Conclusions

Chapter 15. Cell senescence is a cause of frailty

What is frailty?

How is frailty assessed in humans?

How is frailty defined and assessed in experimental animals?

What are the possible causes of frailty?

What is cell senescence?

Does cell senescence cause frailty? How good is the evidence for it?

Conclusions

Part 3. Conclusions

Chapter 16. Senescence as a therapeutic target: current state and future challenges

Biological interpretations of cellular senescence

Tissue remodeling by senescence is a two-step process

The two steps of senescence in cancer

The two steps of senescence in disease

SASP-induced tissue repair versus SASP-induced tissue dysfunction

Molecular triggers of senescence

Triggers of senescence in vivo

The challenge of detecting cellular senescence in clinical settings

Potential side effects of eliminating senescent cells

Senolytics as an anti-aging strategy

Index

People also search for Cellular Senescence in Disease 1st Edition:

    
the role of cellular senescence in ageing and endocrine disease
    
redox changes and cellular senescence in alzheimer’s disease
    
cellular senescence in renal ageing and disease
    
cellular senescence in musculoskeletal homeostasis diseases and regeneration
    
cellular senescence in development regeneration and disease

Tags: Manuel Serrano, Daniel Munoz Espin, Cellular Senescence, Disease