Chondrosarcoma Biology and Clinical Management 1st Edition by Francis Hornicek ISBN 9783030745721

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ISBN 10: 
ISBN 13: 9783030745721
Author: Francis Hornicek

Chondrosarcoma, a rare cancer that develops from cartilage cells, occurs mainly in the bones but can also appear in the soft tissue of the pelvis, hip and shoulder. Unfortunately, these cancers are highly resistant to both chemotherapy and radiation, and no successful adjuvant therapies currently exist. As such, surgical treatment and resection remain the mainstays of management for patients with these tumors.

This concise text is a comprehensive presentation of the current knowledge regarding the development, diagnosis and management of chondrosarcomas. Part I discusses pathology, molecular biology and imaging features of chondrosarcomas. The different types of skeletal and extraskeletal tumors are presented in detail in part II, including conventional and secondary tumors. Management approaches are outlined and described in part III – limb salvage surgery is the most common, and although less effective, radiation and chemotherapy are indicated in certain cases. Part IV examines the future of chondrosarcoma management and development of novel adjuvant therapies, as well as the relationship of this disease to similar types (e.g., chordoma).

 Bringing together the most up-to-date information on this rare cancer, Chondrosarcoma will be a valuable resource for orthopedic oncologists, researchers and all medical professionals treating these challenging tumors. 

Chondrosarcoma Biology and Clinical Management 1st Edition Table of contents:

Chapter 1: Introduction to Chondrosarcoma
1.1 What is Chondrosarcoma?
1.2 Epidemiology and Risk Factors
1.3 Classification of Chondrosarcoma
1.4 Clinical Presentation and Symptoms
1.5 Prognosis and Survival Rates

Chapter 2: Molecular and Genetic Basis of Chondrosarcoma
2.1 The Role of Cartilage and Cartilage Cells in Chondrosarcoma
2.2 Genetic Mutations and Pathways in Chondrosarcoma
2.3 Molecular Markers and Their Diagnostic Value
2.4 The Role of the Microenvironment in Tumor Growth
2.5 Advances in Genomic Research on Chondrosarcoma

Chapter 3: Diagnostic Approaches to Chondrosarcoma
3.1 Clinical Assessment and Physical Examination
3.2 Imaging Techniques: X-Ray, MRI, and CT Scans
3.3 Biopsy and Histopathological Examination
3.4 Molecular Diagnostics: Genetic and Biomarker Testing
3.5 Challenges in Early Diagnosis and Detection

Chapter 4: Staging and Prognostic Factors
4.1 Staging Systems for Chondrosarcoma
4.2 Histological Grading and Its Impact on Prognosis
4.3 Molecular Prognostic Markers
4.4 The Role of Tumor Size and Location in Prognosis
4.5 Metastasis and Its Influence on Outcomes

Chapter 5: Treatment Strategies for Chondrosarcoma
5.1 Surgical Management: Techniques and Considerations
5.2 Limb Salvage Surgery vs. Amputation
5.3 The Role of Radiation Therapy
5.4 Chemotherapy in Chondrosarcoma: Current Evidence and Challenges
5.5 Emerging Targeted Therapies and Immunotherapy
5.6 Multidisciplinary Approach to Treatment

Chapter 6: Management of Recurrence and Metastasis
6.1 Strategies for Managing Local Recurrence
6.2 Treatment of Metastatic Chondrosarcoma
6.3 The Role of Recurrent Surgery and Alternative Therapies
6.4 The Impact of Recurrence on Patient Outcomes

Chapter 7: Long-Term Follow-Up and Survivorship
7.1 Monitoring for Recurrence: Imaging and Clinical Follow-Up
7.2 Psychological and Emotional Aspects of Survivorship
7.3 Rehabilitation and Quality of Life After Treatment
7.4 Survivorship Care Plans and Multidisciplinary Support

Chapter 8: Advances in Research and Future Directions
8.1 Current Clinical Trials and Research in Chondrosarcoma
8.2 Investigating New Molecular Targets for Treatment
8.3 Advances in Personalized Medicine for Chondrosarcoma
8.4 The Role of Immunotherapy and Gene Therapy
8.5 Future Directions in Early Detection and Treatment

Chapter 9: Case Studies in Chondrosarcoma Management
9.1 Case Study 1: Diagnosis and Surgical Treatment of Primary Chondrosarcoma
9.2 Case Study 2: Chemotherapy and Radiation Therapy in Metastatic Chondrosarcoma
9.3 Case Study 3: Managing Recurrence and Post-Surgical Care
9.4 Lessons Learned from Real-World Clinical Experiences

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Francis Hornicek,Chondrosarcoma,Biology,Clinical Management