Current Concepts in Arrhythmogenic Cardiomyopathy 2nd Edition by Corinna Brunckhorst, Ardan M Saguner, Firat Duru ISBN 1942909519 9781942909507

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ISBN 10: 1942909519
ISBN 13: 9781942909507
Author: Corinna Brunckhorst, Ardan M Saguner, Firat Duru

Current Concepts in Arrhythmogenic Cardiomyopathy 2nd Edition Table of contents:

Chapter 1: The History of Naxos Disease: Landmarks in the History of the Disorder

Clinical Observations

Description of a New Syndrome

Nomenclature and Genetic Studies

Clinical Projects and Collaborations

References

Chapter 2: Metabolic Deregulation in Arrhythmogenic Cardiomyopathy: Novel Pathogenic Insights and Th

Introduction

Pathologies andPathogenic Mechanisms of Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

Establishing iPSCs from Patients with Clinical ARVC and Desmosome Gene Mutations

Metabolic Maturation-based Pathogenic Induction of ARVC Pathologies

Conclusions and Future Perspective

References

Chapter 3: Pleiotropic Functions of Plakophilin-2 and Arrhythmia Mechanisms

Introduction

Conclusions

References

Chapter 4: Immune Signaling in Arrhythmogenic Cardiomyopathy

Introduction

Inhibition of NFκB Signaling Reverses ACM Disease Features In Vitro

Inhibition of NFκB Signaling Prevents Development of ACM Disease Features In Vivo

The Heart Contains Abundant Cytokines in ACM

Discussion

References

Chapter 5: Studying Arrhythmogenic Cardiomyopathy Under the Microscope

Introduction

Pathological Anatomy of ARVC

From ARVC to AC, Recognizing the Wider Phenotypic Spectrum

Nonischemic LV Scar

Role of Transvenous Endomyocardial Biopsy

References

Chapter 6: Genetic Contributions to Arrhythmogenic Cardiomyopathy

Introduction

Syndromic ACM

Nonsyndromic Desmosomal ACM

Nondesmosomal ACM

Whole Exome Sequencing Studies

Reduced Penetrance

Relevance of Genetic Testing

Summary and Future Directions

References

Chapter 7: Current Challenges in the Diagnosis of Arrhythmogenic Cardiomyopathies

Introduction

Diagnosis in Biventricular and Predominant LV Disease

Electrocardiographic Challenges in ACM Diagnosis

Genetic Challenges in ACM Diagnosis

Conclusion

References

Chapter 8: Differential Diagnosis of Phenotypic Variants of Arrhythmogenic Cardiomyopathy

Introduction

Differential Diagnosis of ARVC

Differential Diagnosis of Left-Dominant and Biventricular ALVC

The 2019 HRS Expert Consensus Statement on Arrhythmogenic Cardiomyopathy

Summary

References

Chapter 9: Life-Threatening Arrhythmias Without Overt Clinical Disease: “Concealed”Arrhythmogeni

Introduction

Clinical Phases of ARVC

Concealed Phase of ARVC

Representative Cases of Concealed ARVC

Molecular Insights of Concealed ARVC and Sudden Death

Clinical Implications of “Concealed Phase” ARVC

Take-Home Messages

References

Chapter 10: Genotype-Phenotype Correlations in ACM: The Chinese Experience

Introduction

Genotype-Clinical Phenotype in Fuwai ACM Cohort

Genotype-Based Clinicopathology: The Fuwai Classification of ACM

Conclusion

References

Chapter 11: Biomarkers in Inherited Arrhythmias: Arrhythmogenic Right Ventricular Cardiomyopathy and

Introduction

Novel Biomarker for Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

Novel Biomarker Profile for Brugada Syndrome

Other Biomarkers in Inherited Arrhythmias

Autoimmunity as a Target for Therapy in Inherited Arrhythmias (ACM)

References

Chapter 12: Atrial Fibrillation and ECG Markers of Atrial Involvement in Arrhythmogenic Right Ventri

Introduction

Prevalence of Atrial Fibrillation in ARVC

Pathophysiologic Mechanisms of AF in ARVC Patients

P-Wave Indices as Indicators of Atrial Involvement in ARVC

Conclusion

References

Chapter 13: Medical Therapy in Arrhythmogenic Right Ventricular Cardiomyopathy

Introduction

Available Medical Therapies

Developing Medical Therapy to Slow or Prevent Disease Progression

Medical Therapy for ARVC: Does One Size Fit All?

References

Chapter 14: Role of Catheter Ablation in Arrhythmogenic Right Ventricular Cardiomyopathy

Introduction

Catheter Ablation in ARVC

References

Chapter 15: Arrhythmogenic Right Ventricular Cardiomyopathy Research: Better Together

Introduction

Challenges and Achievements After 20 Years of a Large Registry: The North American Experience

Using Infrastructure for a Successful National Collaboration: The DutchExperience

Joint Successes

Predicting Arrhythmic Risk

Toward the Future

References

Chapter 16: The Role of Protein Redistribution in the Diagnosis of Arrhythmogenic Cardiomyopathy: A

Introduction

Protein Remodeling in the ACM Myocardium

The Molecular Signature of ACM

Protein Remodeling in the ACM Buccal Epithelium

References

Chapter 17: The Zurich ARVC Program

Introduction

ARVC Registry and Biobank

Research Projects

Clinical Research

Translational Research

Zurich International Symposium on Arrhythmogenic Cardiomyopathies

Conclusions

References

Impressions from the Zurich International Symposium on Arrhythmogenic Cardiomyopathies 2019

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Tags: Corinna Brunckhorst, Ardan M Saguner, Firat Duru, Arrhythmogenic Cardiomyopathy