Cytogenomics 1st Edition by Thomas Liehr Editor 0128235799 978-0128235799

Cytogenomics 1st Edition Thomas Liehr Editor – Ebook PDF Instant Download/Delivery ISBN(s): 0128235799, 978-0128235799

Product details:

• ISBN 10:0128235799
• ISBN 13:978-0128235799
• Author: Thomas Liehr editor

Cytogenomics demonstrates that chromosomes are crucial in understanding the human genome and that new high-throughput approaches are central to advancing cytogenetics in the 21st century. After an introduction to (molecular) cytogenetics, being the basic of all cytogenomic research, this book highlights the strengths and newfound advantages of cytogenomic research methods and technologies, enabling researchers to jump-start their own projects and more effectively gather and interpret chromosomal data. Methods discussed include banding and molecular cytogenetics, molecular combing, molecular karyotyping, next-generation sequencing, epigenetic study approaches, optical mapping/karyomapping, and CRISPR-cas9 applications for cytogenomics. The book’s second half demonstrates recent applications of cytogenomic techniques, such as characterizing 3D chromosome structure across different tissue types and insights into multilayer organization of chromosomes, role of repetitive elements and noncoding RNAs in human genome, studies in topologically associated domains, interchromosomal interactions, and chromoanagenesis.

Table contents:

Chapter 1: A definition for cytogenomics – Which also may be called chromosomics
Chapter 2: Overview of currently available approaches used in cytogenomics
Chapter 3: Cytogenetics
Chapter 4: Molecular cytogenetics
Chapter 5: Molecular combing solutions to characterize replication kinetics and genome rearrangements
Chapter 6: Molecular karyotyping
Chapter 7: Sequencing approaches
Chapter 8: Next-generation cytogenomics: High-resolution structural variation detection by optical genome mapping
Chapter 9: Application of CRISPR/Cas9 to visualize defined genomic sequences in fixed chromosomes and nuclei
Chapter 10: Approaches for studying epigenetic aspects of the human genome
Chapter 11: Chromoanagenesis phenomena and their formation mechanisms
Chapter 12: 3D cytogenomics: Structural variation in the three-dimensional genome
Chapter 13: Multilayer organization of chromosomes
Chapter 14: Nuclear architecture
Chapter 15: Nuclear stability in early embryo. Chromosomal aberrations
Chapter 16: Cytogenomic landscape of the human brain
Chapter 17: Interchromosomal interactions with meaning for disease
Chapter 18: Shaping of genome by long noncoding RNAs
Chapter 19: Repetitive elements, heteromorphisms, and copy number variants
Chapter 20: Epigenetics

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