Fetal and Neonatal Physiology 2 Volume Set 6th Edition by Richard A Polin, Steven H Abman, David Rowitch, William E Benitz ISBN 9780323712842 0323712843

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ISBN 10: 0323712843
ISBN 13: 9780323712842
Author: Richard A Polin, Steven H Abman, David Rowitch, William E Benitz

Offering the comprehensive, authoritative information needed for effective diagnosis, treatment, and management of sick and premature infants, Fetal and Neonatal Physiology, 6th Edition, is an invaluable resource for board review, clinical rounds, scientific research, and day-to-day practice. This trusted two-volume text synthesizes recent advances in the field into definitive guidance for today’s busy practitioner, focusing on the basic science needed for exam preparation and key information required for full-time practice. It stands alone as the most complete text available in this complex and fast-changing field, yet is easy to use for everyday application.

• Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants. 

• Contains new chapters on Pathophysiology of Genetic Neonatal Disease, Genetic Variants and Neonatal Disease, and Developmental Biology of Lung Stem Cells,  as well as significantly revised chapters on Cellular Mechanisms of Neonatal Brain Injury, Neuroprotective Therapeutic Hypothermia, Enteric Nervous System Development and Gastrointestinal Motility, and Physiology of Twin-Twin Transfusion. 

• Features 1,000 full-color diagrams, graphs and anatomic illustrations, 170 chapters, and more than 350 global contributors. 

• Includes chapters devoted to clinical correlation that help explain the implications of fetal and neonatal physiology, as well as clinical applications boxes throughout. 

• Provides summary boxes at the end of each chapter and extensive cross-referencing between chapters for quick reference and review. 

• Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more

Fetal and Neonatal Physiology 2 Volume Set 6th Edition Table of contents:

Section I. Genetics and Embryology

1. Basic Genetic Principles

2. Epigenetics

3. Basic Embryology

4. Regulation of Embryogenesis

5. The Extracellular Matrix in Development

6. Angiogenesis

7. Prenatal Diagnosis

Section II. Placenta and Intrauterine Environment

8. Placental Development

9. Regulation of the Placental Circulation

10. Mechanisms of Transfer Across the Human Placenta

11. Endocrine and Paracrine Function of the Human Placenta

12. Intra-Amniotic Infection/Inflammation and the Fetal Inflammatory Response Syndrome

13. Fetal Origins of Adult Disease: A Classic Hypothesis With New Relevance

14. Placental Function in Intrauterine Growth Restriction

Section III. Developmental Pharmacology

15. Basic Pharmacologic Principles

16. Principles of Pharmacokinetics

17. The Physiology of Placental Drug Disposition

18. Pharmacogenomics

19. Drug Distribution in Fetal Life

20. Drug Transfer During Breastfeeding

Section IV. Intrauterine and Postnatal Growth

21. Placental and Fetal Circulatory and Metabolic Changes Accompanying Fetal Growth Restriction

22. Endocrine Factors Affecting Neonatal Growth

23. Human Milk Composition and Function in the Infant

24. Physiology of Lactation

Section V. Perinatal Iron, Mineral, and Vitamin Metabolism

25. Fetal and Neonatal Iron Metabolism

26. Fetal and Neonatal Calcium, Phosphorus, and Magnesium Homeostasis

27. Zinc in the Fetus and Neonate

28. Vitamin A Metabolism in the Fetus and Neonate

29. Vitamin E Nutrition in Pregnancy and the Newborn Infant

30. Vitamin K Metabolism in the Fetus and Neonate

Section VI. Lipid Metabolism

31. Maternal-Fetal Transfer of Lipid Metabolites

32. Brown Adipose Tissue: Development and Function

33. Lipids as an Energy Source for the Premature and Term Neonate

34. Ketone Body Metabolism in the Neonate

35. Long-Chain Polyunsaturated Fatty Acids in Neurodevelopment

Section VII. Carbohydrate Metabolism

36. Glucose Metabolism in the Fetus and Newborn, and Methods for Its Investigation

37. Oxygen Consumption and General Carbohydrate Metabolism of the Fetus

38. Role of Glucoregulatory Hormones in Hepatic Glucose Metabolism During the Perinatal Period

39. Cell Glucose Transport and Glucose Handling During Fetal and Neonatal Development

Section VIII. Protein Metabolism

40. General Concepts of Protein Metabolism

41. Placental Transfer and Fetal Requirements of Amino Acids

Section IX. Thermoregulation

42. Temperature Control in Newborn Infants

Section X. Skin

43. Structure and Development of the Skin and Cutaneous Appendages

44. Physiologic Development of the Skin

Section XI. Fetal and Neonatal Cardiovascular Physiology

45. Cardiovascular Development

46. Developmental Electrophysiology in the Fetus and Neonate

47. Developmental Biology of the Pulmonary Vasculature

48. Development of the Gastrointestinal Circulation in the Fetus and Newborn

49. Physiology of Congenital Heart Disease in the Neonate

50. Regulation of Cardiovascular Function During Fetal and Newborn Life

51. Nutritional and Environmental Effects on the Fetal Circulation

52. Mechanisms Regulating Closure of the Ductus Arteriosus

53. Umbilical Circulation

54. Fetal and Placental Circulation During Labor

Section XII. The Lung

55. Normal and Abnormal Structural Development of the Lung

56. Regulation of Alveolarization

57. Physiologic Mechanisms of Normal and Altered Lung Growth Before and After Birth

58. Molecular Mechanisms of Lung Development and Lung Branching Morphogenesis

59. Regulation of Liquid Secretion and Absorption by the Fetal and Neonatal Lung

60. Upper Airway Structure: Function, Regulation, and Development

61. Regulation of Lower Airway Function

62. Functional Development of Respiratory Muscles

63. Mechanics of Breathing

64. Pulmonary Gas Exchange in the Developing Lung

65. Oxygen Transport and Delivery

66. Control of Breathing in Fetal Life and Onset and Control of Breathing in the Neonate

67. Basic Mechanisms of Oxygen Sensing and Adaptation to Hypoxia

68. Evaluation of Pulmonary Function in the Neonate

69. Mechanisms of Neonatal Lung Injury

70. Impaired Lung Growth After Injury in Preterm Lung

71. Antenatal Factors That Influence Postnatal Lung Development and Injury

72. Regulation of Pulmonary Circulation

Section XIII. Surfactant

73. Historical Perspective

74. Developmental Biology of Lung Stem Cells

75. Surfactant Homeostasis: Composition and Function of Pulmonary Surfactant Lipids and Proteins

76. Structure and Development of Alveolar Epithelial Cells

77. Regulation of Surfactant-Associated Phospholipid Synthesis and Secretion

78. Antenatal Hormonal Therapy for Prevention of Respiratory Distress Syndrome

79. Surfactant Treatment

80. Genetics and Physiology of Surfactant Protein Deficiencies

Section XVI. Physiology of Gastrointestinal Tract in the Fetus and Neonate

81. Trophic Factors and Regulation of Gastrointestinal Tract and Liver Development

82. Organogenesis of the Gastrointestinal Tract

83. Development of Gastric Secretory Function

84. Development of the Enteric Nervous System and Gastrointestinal Motility

85. Development of the Endocrine and Exocrine Pancreas

86. Digestive-Absorptive Functions in Fetuses, Infants, and Children

87. The Developing Microbiome of the Fetus and Neonate: A Multiomic Approach

Section XV. Liver and Bilirubin Metabolism

88. Organogenesis and Histologic Development of the Liver

89. Bile Acid Metabolism During Development

90. Fetal and Neonatal Bilirubin Metabolism

91. Hereditary Contributions to Neonatal Hyperbilirubinemia

92. Mechanistic Aspects of Phototherapy for Neonatal Hyperbilirubinemia

Section XVI. The Kidney

93. Development of the Kidney: Morphology and Mechanisms

94. Functional Development of the Kidney in Utero

95. Development and Regulation of Renal Blood Flow in the Neonate

96. Postnatal Development of Glomerular Filtration Rate in Neonates

97. Renal Transport of Sodium During Development

98. Potassium Homeostasis in the Fetus and Neonate

99. Role of the Kidney in Calcium and Phosphorus Homeostasis

100. Transport of Amino Acids in the Fetus and Neonate

101. Organic Anion Transport in the Developing Kidney

102. Concentration and Dilution of Urine

103. Urinary Acidification

104. Response to Nephron Loss in Early Development

Section XVII. Fluid and Electrolyte Metabolism

105. Fluid Distribution in the Fetusand Neonate

106. Regulation of Acid-Base Balance in the Fetus and Neonate

Section XVIII. Developmental Hematopoiesis

107. Developmental Biology of Hematopoietic Stem Cells

108. Neutrophil Granulopoiesis and Homeostasis

109. Developmental Erythropoiesis

110. Developmental Megakaryopoiesis

Section XIX. Hemostasis

111. Developmental Hemostasis

112. Platelet–Vessel Wall Interactions

Section XX. Developmental Immunobiology

113. Host Defense Mechanisms Against Bacteria

114. Host Defense Mechanisms Against Fungi

115. Host Defense Mechanisms Against Viruses

116. T-Cell Development

117. B-Cell Development

118. Mononuclear Phagocyte System

119. Normal and Abnormal Neutrophil Physiology in the Newborn

120. The Complement System of the Fetus and Newborn

121. Cytokines and Inflammatory Response in the Fetus and Neonate

122. Immunology of Human Milk

123. Neonatal Pulmonary Host Defense

Section XXI. Neurology

124. Development of the Nervous System

125. Mechanisms of Cell Death in the Developing Brain

126. Development of the Blood-Brain Barrier

127. Trophic Factor, Nutritional, and Hormonal Regulation of Brain Development

128. Developmental Aspects of Pain

129. Cerebellar Development—The Impact of Preterm Birth and Comorbidities

130. Electroencephalography in the Preterm and Term Infant

131. Intraventricular Hemorrhage in the Neonate

132. Pathophysiology of Neonatal White Matter Injury

133. Cellular and Molecular Mechanisms of Neonatal Brain Injury and Neuroprotection

134. Neuroprotective Therapeutic Hypothermia

Section XXII. Special Sensory Systems in the Fetus and Neonate

135. Early Development of the Human Auditory System

136. Development of Olfaction and Taste in the Human Fetus and Neonate

Section XXIII. Musculoskeletal

137. The Growth Plate: Embryologic Origin, Structure, and Function

138. Ontogenesis of Striated Muscle

Section XXIV. Endocrine Function

139. Hypothalamus: Neuroendometabolic Center

140. Growth Factor Regulation of Fetal Growth

141. Growth Hormone, Prolactin, and Placental Lactogen in the Fetus and Newborn

142. Luteinizing Hormone and Follicle-Stimulating Hormone Secretion in the Fetus and Newborn Infant

143. Development of the Hypothalamus-Pituitary-Adrenal Axis in the Fetus

144. Fetal and Neonatal Adrenocortical Physiology

145. Fetal and Neonatal Thyroid Physiology

Section XXV. Ovary and Testis

146. Genetics of Sex Determination and Differentiation

147. Differentiation of the Ovary

148. Testicular Development and Descent

Section XXVI. Pathophysiology of Neonatal Diseases

149. The Pathophysiology of Twin-Twin Transfusion Syndrome, Twin-Anemia Polycythemia Sequence, and Twin-Reversed Arterial Perfusion

150. Physiology of Neonatal Resuscitation

151. Pathophysiology of Neonatal Sepsis

152. Pathophysiology of Neonatal Hypoglycemia

153. Pathophysiology of Cardiomyopathies

154. Pathophysiology of Persistent Pulmonary Hypertension ofthe Newborn

155. Pathophysiology of Shock in theFetus and Neonate

156. Pathophysiology of Apnea of Prematurity

157. Pathophysiology of Respiratory Distress Syndrome

158. Pathophysiology of Meconium Aspiration Syndrome

159. Pathophysiology of Bronchopulmonary Dysplasia

160. Pathophysiology of Ventilator-Dependent Infants

161. Pathophysiology of Gastroesophageal Reflux

162. Pathophysiology and Prevention of Neonatal Necrotizing Enterocolitis

163. Pathophysiology of Kernicterus

164. Pathophysiology of Neonatal AcuteKidney Injury

165. Pathophysiology of Edema

166. Pathophysiology of Retinopathy of Prematurity

167. Pathophysiology of Neonatal Hypoxic-Ischemic Brain Injury

168. Pathophysiology of Neonatal Acute Bacterial Meningitis

169. Pathophysiology of NeuralTube Defects

170. Pathophysiology of Preeclampsia

171. Pathophysiology of Preterm Birth

172. Pathophysiology of Chorioamnionitis: Host Immunity and Microbial Virulence

173. Pathophysiology of Genetic Neonatal Disease

174. Genetic Variants and Neonatal Disease

Index

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Tags: Richard A Polin, Steven H Abman, David Rowitch, William E Benitz, Neonatal Physiology