Oncogenomics From Basic Research to Precision Medicine 1st Edition by Franco Dammacco, Francesco Silvestris 0128117850 9780128117859

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ISBN 10: 0128117850

ISBN 13: 9780128117859

Author: Franco Dammacco, Francesco Silvestris

Oncogenomics: From Basic Research to Precision Medicine offers a thorough survey of precision medicine and its diagnostic and therapeutic applications in oncology. Gathering contributions from leading international researchers in the field, chapters examine recent translational advances in oncogenomic methods and technologies, detailing novel molecular classifications of tumors as well as diagnostic and prognostic biomarkers for various types of cancers including pancreatic, gastrointestinal, breast, hematological, lung, osteotropic, genitourinary, and skin cancers. This book provides a foundation for clinical oncologists, human geneticists, and physicians to develop new targeted cancer treatments and incorporate genomic medicine into clinical practice, with particular attention paid to noninvasive diagnostic techniques such as the liquid biopsy and molecular characterization of solid malignancies.

Oncogenomics From Basic Research to Precision Medicine 1st Table of contents:

I. Molecular Medicine: A Novel Approach to Cancer Investigation

1. From the Double Helix to Oncogenomics and Precision Cancer Medicine: An Evolving Story
2. Intratumor Heterogeneity: Biological and Clinical Implications
3. The Role of Proteomics in Cancer Research
4. Next-Generation Sequencing in Clinical Practice
5. Cancer Epigenetics: Aberrant DNA Methylation in Cancer Diagnosis and Treatment
6. Cancer Stem Cells: Role in Tumor Progression and Treatment Resistance
7. Cancer Stem Cells, Apoptosis Pathways and Mechanisms of Death Resistance
8. Targeting the Hedgehog and Notch Signaling Pathways in Cancer Stem Cells
9. Cancer Stem Cells in Multiple Myeloma and the Development of Novel Therapeutic Strategies

II. Oncogenomics: Circulating Biomarkers in Clinical Oncology
10. Bone Metastases from Solid Tumors: In Search of Predictive Biomarkers for Clinical Translation
11. Liquid Biopsy and Genomic Assessment for Lung Cancer: The Role in Clinical Practice
12. Prognostic and Predictive Role of Circulating Tumor Cells
13. Circulating miRNAs as Tumor Biomarkers
14. Circulating DNA in Cancer Diagnosis and Prognosis
15. Sequencing a Single Circulating Tumor Cell for Genomic Assessment
16. Single Nucleotide Polymorphisms in Cancer Research and Treatment

III. Gastrointestinal Tumors: Molecular Diagnosis and Treatment
17. Gastric Cancers: A Molecular Roadmap for Patient Stratification and Targeted Therapies
18. Resistance to EGFR Targeting Treatments in Colorectal Cancer
19. Circulating DNA and Protein Biomarkers for the Treatment of Metastatic Colorectal Cancer
20. Rationale for Immunotherapy in Gastrointestinal Malignancies
21. Proteomics Profiling of Pancreatic Cancer: Roles in Biomarker Discovery
22. Emerging Technologies for the Diagnosis and Treatment of Pancreatic Cancer
23. Personalized Medicine in Gastrointestinal Stromal Tumors
24. Circulating MicroRNAs as Tumor Biomarkers in Hepatocellular Carcinoma

IV. Perspectives in Breast Cancer Genomics
25. Gene Profiles in Breast Cancer: Translation to Clinical Medicine
26. Novel Biomarkers Predicting the Development of Bone Metastasis in Early Breast Cancer
27. HER2-Positive Early Breast Cancer: Affordable Risks, Affordable Therapies, and New Developments
28. Role of Circulating Tumor Cells in Breast Cancer Patients
29. Overcoming Endocrine Resistance in Breast Cancer: mTOR Inhibitors and New Drugs
30. Explore Genomic Profiles for Triple-Negative Breast Cancer to Discover Drug Targets

V. Lung Cancer: Role of Genomics in Clinical Practice
31. Gene Fusion in NSCLC: ALK, ROS1, RET, and Related Treatments
32. Circulating Tumor Cells and ctDNA in NSCLC: A Role for Treatment Decision
33. EGFR Mutations: Best Results from Second- and Third-Generation Tyrosine Kinase Inhibitors
34. Immuno-Oncology in Lung Cancer: A Focus on Anti-PD-1 and Anti-CTLA-4 Therapy in NSCLC

VI. Genomics in Genitourinary Cancer
35. Molecular Assessment of Ovarian Cancer and Translation to Clinical Management
36. Development of PARP Inhibitors for BRCA-Deficient Epithelial Ovarian Cancer
37. New Treatment Options for Ovarian Cancer
38. Emerging Immunotherapies for Renal Cell Carcinoma
39. TKIs in Renal Cell Carcinoma: What Can We Expect in the Future?
40. Circulating Tumor Cells as Surrogate Biomarker for Overall Survival in Metastatic Prostate Cancer

VII. Genomics in Neuroendocrine Tumors, Melanoma, and Sarcoma
41. Management of NETs in the Precision Medicine Era
42. Immunological and Genetic Biomarkers of Sarcomas: Implication for Future Treatment Strategies
43. Advances in Sarcoma Genomics and Therapeutic Management
44. Molecular Pathways in Melanomagenesis: Characterization of New Therapeutic Targets
45. Immunotherapies and Novel Combinations: Advances in the Treatment of Melanoma
46. BRAF-Mutant Melanoma: Treatment Approaches and Resistance Mechanisms

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Franco Dammacco,Francesco Silvestris,Oncogenomics,Medicine