Pathologic Basis of Veterinary Disease 7th Edition by James F Zachary ISBN 9780323713139 0323713130

Section I. Cellular and Molecular Mechanisms of Disease (General Pathology)

Introduction

Chapter 1. Mechanisms and Morphology of Cellular Injury, Adaptation, and Death

Introduction

Normal Cell

Causes of Cell Injury

Irreversible Cell Injury and Cell Death

Chronic Cell Injury and Cell Adaptations

Cell Cycle

Cellular Aging

Genetic Basis of Disease

Chapter 2. Vascular Disorders and Thrombosis

Introduction

Circulatory System

Microcirculation, Interstitium, and Cells

Fluid Distribution and Homeostasis

Abnormal Fluid Distribution

Hemostasis

Disorders of Hemostasis: Hemorrhage and Thrombosis

Normal Blood Flow, Distribution, and Perfusion

Alterations in Blood Flow and Perfusion

Shock

Chapter 3. Inflammation and Healing

Introduction

Evolution of the Current Understanding of Inflammation

Beneficial and Harmful Aspects of Inflammation

Acute Inflammation

Substances Inducing the Acute Inflammatory Response

Fluidic (Exudative) Phase of the Acute Inflammatory Response

Cellular Phase of the Acute Inflammatory Response

Additional Regulation of Inflammation

Inflammation and Pain

Effector Cells of the Acute Inflammatory Response

Chemical Mediators of the Acute Inflammatory Response

Reparative Phase of the Acute Inflammatory Response

Nomenclature of the Inflammatory Response (Morphologic Diagnoses)

Morphologic Classification of Exudates in Acute Inflammatory Lesions

Chronic Inflammation

Beneficial and Harmful Aspects of Chronic Inflammation

Progression of the Acute Inflammatory Response to Chronic Inflammation, Fibrosis, and Abscess Formation

Gross and Microscopic Lesions and Nomenclature of the Chronic Inflammatory Response

Effector Cells and Cellular Mechanisms of Chronic Inflammatory Responses

Inflammation and the Sensation of Pain

The Effect of Inflammation on the Febrile Response and Other Activities

Unique Types of Inflammation

Cytologic and Histologic Comparisons of Inflammatory Exudates

Wound Healing and Angiogenesis

Chapter 4. Mechanisms of Microbial Infections

Introduction

Chronologic Sequence of Steps in Microbial Diseases

Portals of Entry

Target Cells and Substances

Pathways of Spread

Defense Mechanisms

Genetic Resistance of Animals to Infectious Diseases

Bacterial Diseases

Viral Diseases

Fungal Diseases (Mycoses)

Protozoan Diseases

Prion Diseases (Spongiform Encephalopathies)

Chapter 5. Diseases of Immunity

General Features of the Immune System

Innate Immunity (Nonspecific Immunity)

Adaptive Immunity (Specific Immunity)

Disorders of the Immune System

Chapter 6. Neoplasia and Tumor Biology

Introduction

General Nomenclature

Tumor Characteristics (Essential Concept 6.1)

Neoplastic Transformation (Essential Concept 6.2)

Tumor Microenvironment (Essential Concept 6.3)

Tumor Immunity (see Essential Concept 6.3)

Tumor Dissemination (Essential Concept 6.4)

Systemic Clinical Effects on the Animal (see Essential Concept 6.3)

Heritable Alterations in Cancer (Essential Concept 6.5)

Molecular Determinants of Cancer

Mechanisms of Carcinogenesis

Cancer in Animals

Section II. Pathology of Organ Systems

Introduction

Chapter 7. Alimentary System and the Peritoneum, Omentum, Mesentery, and Peritoneal Cavity

Introduction

Structure and Function

Dysfunction/Responses to Injury

Portals of Entry/Pathways of Spread

Defense Mechanisms/Barrier Systems

Diseases Affecting Multiple Species of Domestic Animalsc,d

Diseases of Horses

Diseases of Ruminants (Cattle, Sheep, and Goats)

Diseases of Pigs

Diseases of Dogs

Diseases of Cats

Chapter 8. Hepatobiliary System and Exocrine Pancreas

Liver and Intrahepatic Biliary System

Gallbladder and Extrahepatic Bile Ducts

Exocrine Pancreas

Chapter 9. Respiratory System, Thoracic Cavities, Mediastinum, and Pleurae

Introduction

Structure and Function

Dysfunction/Responses to Injury

Portals of Entry/Pathways of Spread

Defense Mechanisms/Barrier Systems

Diseases Affecting Multiple Species of Domestic Animals

Diseases of Horses

Diseases of Ruminants (Cattle, Sheep, and Goats)

Diseases of Pigs

Diseases of Dogs

Diseases of Cats

Chapter 10. Cardiovascular System, Pericardial Cavity, and Lymphatic Vessels

Structure

Function

Dysfunction/Responses to Injury

Portals of Entry/Pathways of Spread

Defense Mechanisms/Barrier Systems

Diseases Affecting Multiple Species of Domestic Animals

Diseases of Horses

Diseases of Ruminants (Cattle, Sheep, and Goats)

Diseases of Pigs

Diseases of Dogs

Diseases of Cats

Chapter 11. The Urinary System

Kidney

Lower Urinary Tract

Chapter 12. Endocrine System

Structure and Function

Dysfunction/Responses to Injury

Portals of Entry/Pathways of Spread

Defense Mechanisms/Barrier Systems

Diseases Affecting Multiple Species of Domestic Animals

Diseases of Horses

Diseases of Ruminants (Cattle, Sheep, and Goats)

Diseases of Pigs

Diseases of Dogs

Diseases of Cats

Chapter13. Bone Marrow, Blood Cells, and the Lymphoid/Lymphatic System

Introduction

Bone Marrow and Blood Cells

Chapter 14. Nervous System

The Nervous System

Central Nervous System

Peripheral Nervous System

Chapter 15. Skeletal Muscle

Structure

Function

Dysfunction/Responses to Injury

Portals of Entry/Pathways of Spread

Defense Mechanisms/Barrier Systems

Diseases Affecting Multiple Species of Domestic Animals

Diseases of Horses

Diseases of Ruminants (Cattle, Sheep, and Goats)

Diseases of Pigs

Diseases of Dogs

Diseases of Cats

Chapter 16. Bones, Joints, Tendons, and Ligaments

Introduction

Structure and Function

Dysfunction/Responses to Injury

Portals of Entry/Pathways of Spread

Defense Mechanisms/Barrier Systems

Diseases Affecting Multiple Species of Domestic Animals

Diseases of Horses

Diseases of Ruminants (Cattle, Sheep, and Goats)

Diseases of Pigs

Diseases of Dogs

Diseases of Cats

Chapter17. The Integument

Structure

Function

Dysfunction/Responses to Injury

Portals of Entry/Pathways of Spread

Defense Mechanisms/Barrier Systems

Diseases Affecting Multiple Species of Domestic Animals

Diseases of Horses

Diseases of Ruminants (Cattle, Sheep, and Goats)

Diseases of Pigs

Diseases of Dogs

Diseases of Cats

E-Appendix 17.1. Postmortem Evaluation of the Skin, Claws, Pawpads, and Hooves

Chapter 18. Female Reproductive System and Mammae

Introduction

E-Appendix 18.1 Techniques Used to Examine the Female Reproductive System and Mammae

Structure

Function

Dysfunction/Responses to Injury

Portals of Entry/Pathways of Spread

Defense Mechanisms/Barrier Systems

Diseases Affecting Multiple Species of Domestic Animals

Diseases of Horses

Diseases of Ruminants (Cattle, Sheep, and Goats)

Diseases of Pigs

Diseases of Dogs

Diseases of Cats

Chapter 19. Male Reproductive System

E-Appendix 19.1 Methods for Examining the Male Reproductive Tract

Introduction

Structure

Function

Dysfunction/Responses to Injury

Portals of Entry/Pathways of Spread

Defense Mechanisms/Barrier Systems

Diseases Affecting Multiple Species of Domestic Animals

Diseases of Horses

Diseases of Ruminants (Cattle, Sheep, and Goats)

Diseases of Pigs

Diseases of Dogs

Diseases of Cats

Chapter 20. The Ear

Introduction

Structure and Function

E-Appendix 20.1. Histologic Evaluation of the Internal Ear

Dysfunction/Responses to Injury

Portals of Entry/Pathways of Spread

Defense Mechanisms/Barrier Systems

Diseases Affecting Multiple Species of Domestic Animals

Diseases of Horses

Diseases of Ruminants (Cattle, Sheep, and Goats)

Diseases of Pigs

Diseases of Dogs

Diseases of Cats

Chapter 21. The Eye

Introduction

Structure and Function

Dysfunction/Response to Injury

Portals of Entry/Pathways of Spread

Defense Mechanisms/Barrier Systems

Diseases Affecting Multiple Species of Domestic Animals

Diseases of Horses

Diseases of Ruminants (Cattle, Sheep, and Goats)

Diseases of Pigs

Diseases of Dogs

Diseases of Cats

E-Appendix 21.1 Postmortem Technique

Section III: Appendices, Veterinary Diagnostic Pathology

Introduction

Appendix A. Communication, Collaboration, and Consultation in Veterinary Pathology

Appendix B. Photographic Techniques in Veterinary Pathology

Appendix C. Postmortem Examination (Autopsy) of Domestic Animal Species

Appendix D. Recognition and Interpretation of Macroscopic (Gross) Lesions

Appendix E. Diagnoses in Veterinary Pathology

Appendix F. General Principles of Tissue Fixation and Processing

Appendix G. Fixatives and Fixation

Appendix H. Fixation and Trimming of the Brain, Spinal Cord, and Nerves

Appendix I. Surgical Biopsies—Procurement, Processing, and Sectioning Artifacts

Appendix J. Gross Examination and Infusion Fixation of the Lung

Appendix K. Necropsy Techniques by Organ System

Index