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Pharmacology of the WNT Signaling System 1st Edition by Gunnar Schulte, Pawel Kozielewicz ISBN 9783030854980 3030854981

Name: Pharmacology of the WNT Signaling System 1st Edition by Gunnar Schulte, Pawel Kozielewicz ISBN 9783030854980 3030854981
SKU: EB-36130186
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Pharmacology of the WNT Signaling System 1st Edition Gunnar Schulte Digital Instant Download

Author(s): Gunnar Schulte, Pawel Kozielewicz

ISBN(s): 9783030854980, 9783030854997, 3030854981, 303085499X

Edition: 1

File Details: EPUB, 30.32 MB

Year: 2021

Language: English

SKU: EB-36130186 Category: Medicine - Pharmacology Tags: Gunnar Schulte, Pawel Kozielewicz

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Pharmacology of the WNT Signaling System 1st Edition by Gunnar Schulte, Pawel Kozielewicz – Ebook PDF Instant Download/Delivery: 9783030854980 ,3030854981
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Product details:
ISBN 10: 3030854981
ISBN 13: 9783030854980
Author: Gunnar Schulte, Pawel Kozielewicz

This book reflects the state of the art of our understanding of the WNT signaling system, which comprises a network of signaling pathways initiated by the secreted WNT lipoglycoproteins, which are crucial for embryonal development, stem cell regulation, tissue homeostasis and repair. Dysfunction of this evolutionarily conserved signaling system leads to many diseases including developmental disorders, diverse forms of cancer, fibrosis, neurodegenerative disease and many more. The WNT signaling system is built upon 19 mammalian, secreted WNT lipoglycoproteins that interact with a plethora of distinct receptors, such as the G protein-coupled receptors called Frizzleds (FZD1-10), LDL receptor-like proteins (LRP5/6), receptor tyrosine kinases (ROR1, 2, RYK and PTK7). In addition, WNT pathways are tightly regulated by many secreted and cell-intrinsic negative regulators, such as soluble FZD-related proteins (SFRPs), Dickkopfs (DKKs), WNT-inhibitory proteins, TIKI, RNF43 and more. Understanding the basic mechanism in terms of receptor-ligand interaction, receptor selectivity, signal initiation and desensitization remain poorly understood, even though substantial advances have been made the recent years. Due to the involvement of the WNT signaling system in human disease, it appears obvious to target diverse branches pharmacologically and therapeutically. However, given the complexity of the system and its importance for stem cell regulation and tissue maintenance, therapy comes with obvious risks for severe side effects. The field is addressing the challenge to identify suitable targets and selective compounds for therapy allowing disease-selective therapeutic effects and balancing unwanted side effects. This book summarizes the current understanding of the basic and applied pharmacology in the WNT signaling system and bridges disciplines such as pharmacology, physiology, neurosciences, oncology and drug development.

Pharmacology of the WNT Signaling System 1st Edition Table of contents:

Part I. Basic Pharmacological Principles of the WNT Signaling System

Controlling Wnt Signaling Specificity and Implications for Targeting WNTs Pharmacologically

Extracellular WNTs: Trafficking, Exosomes, and Ligand–Receptor Interaction

LRPs in WNT Signalling

Targeting the Receptor Tyrosine Kinase ROR1 by Small Molecules

Employing Genetically Encoded, Biophysical Sensors to Understand WNT/Frizzled Interaction and Receptor Complex Activation

Can We Pharmacologically Target Dishevelled: The Key Signal Transducer in the Wnt Pathways?

Zooming in on the WNT/CTNNB1 Destruction Complex: Functional Mechanistic Details with Implications for Therapeutic Targeting

An Overview of Potential Therapeutic Agents Targeting WNT/PCP Signaling

Mining Natural Compounds to Target WNT Signaling: Land and Sea Tales

Part II. Disease-Specific Targeting of the WNT Signaling System

Frizzled7 Activates β-Catenin-Dependent and β-Catenin-Independent Wnt Signalling Pathways During Developmental Morphogenesis: Implications for Therapeutic Targeting in Colorectal Cancer

Targeting Oncogenic WNT Signalling with WNT Signalling-Derived Peptides

WNT Signalling in Lung Physiology and Pathology

WNT Signalling in Osteoarthritis and Its Pharmacological Targeting

WNT Signaling Is a Key Player in Alzheimer’s Disease

Pharmacologically Targeting the WNT/β-Catenin Signaling Cascade: Avoiding the Sword of Damocl

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Tags: Gunnar Schulte, Pawel Kozielewicz, Pharmacology, WNT Signaling System