The Handbook of Medicinal Chemistry Principles and Practice 2nd Edition by Andrew Davis, Simon Ward ISBN 183916588X 9781839165887

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Product details:

ISBN 10: 183916588X

ISBN 13: 978-1839165887

Author:  Andrew M. Davis, Simon E. Ward 

The Handbook of Medicinal Chemistry: Principles and Practice 2nd Edition: 

Completely revised and updated, the 2nd edition of The Handbook of Medicinal Chemistry draws together contributions from authoritative practitioners to provide a comprehensive overview of the field as well as insight into the latest trends and research. An ideal companion for students in medicinal chemistry, drug discovery and drug development, while also communicating core principles, the book places the discipline within the context of the burgeoning platform of new modalities now available to drug discovery. The book also highlights the role chemistry has to play in wider target validation and translational technologies.

This is a carefully curated compilation of writing from global experts using their broad experience of medicinal chemistry, project leadership and drug discovery and development from an industry, academic and charity perspective to provide unparalleled insight into the field.

 

The Handbook of Medicinal Chemistry: Principles and Practice 2nd Edition Table of contents:

1. Physicochemical Properties
2. Synthesis in Medicinal Chemistry
3. Useful Computational Chemistry Tools for Medicinal Chemistry
4. Structure-based Design for Medicinal Chemists
5. Fragment-based Ligand Discovery
6. Machine Learning in Drug Design
7. Drug Metabolism
8. ADME Optimization in Drug Discovery
9. Molecular Biology for Medicinal Chemists
10. Assays
11. In Vitro Biology: Measuring Pharmacological Activity That Will Translate to Clinical Efficacy
12. Animal Models: Practical Use and Considerations
13. Bioinformatics for Medicinal Chemistry
14. Translational Science
15. Discovery Toxicology in Lead Optimization
16. Toxicology and Drug Development
17. Patents for Medicines
18. Target Validation for Medicinal Chemists
19. Lead Optimisation: What You Should Know!
20. Pharmaceutical Properties – The Importance of Solid Form Selection
21. The Medicinal Chemistry and Process Chemistry Interface
22. Clinical Drug Development
23. SMN2 Splicing Modification by Small Molecules – A Blueprint to Tackle the Underlying Genetic Cause of Many Underserved Diseases
24. The Discovery of Checkpoint Kinase 1 Inhibitors: From Fragments to Clinical Candidate
25. Medicinal Chemistry for Neglected Diseases – Malaria, Tuberculosis, Sleeping Sickness, Leishmaniasis, and River Blindness
26. New Therapeutic Chemical Modalities: Compositions, Modes-of-action, and Drug Discovery

 

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