Translational Autoimmunity Volume 1 Etiology of Autoimmune Diseases 1st Edition by Nima Rezaei, Niloufar Yazdanpanah ISBN 9780128225646 0128225645

Chapter 1: Introduction on translational autoimmunity: From bench to bedside

Abstract

1: Introduction

2: Autoimmune disorders

3: Pathogenesis and mechanisms of autoimmune diseases

4: Predisposing factors

5: Role of genetics

6: Obstacles in treatment

7: Diagnostic tools

8: Role of innate immunity

9: Conclusion

Chapter 2: Autophagy in autoimmunity

Abstract

1: Introduction

2: An overview of autophagy

3: Autophagy in immunity

4: Autophagy in autoimmune diseases

5: Conclusion

Chapter 3: Immunometabolism and autoimmunity

Abstract

1: Introduction

2: Immunometabolism in homeostasis

3: Immunometabolism in autoimmunity

4: Conclusion

Chapter 4: T cell recognition of neoepitopes in autoimmunity

Abstract

1: Introduction

2: The mystery of lost tolerance in autoimmunity

3: Determinant spreading in autoimmune disease

4: Neoepitopes as a challenge to immune tolerance

5: T cell recognition of citrullinated neoepitopes in rheumatoid arthritis

6: T cell recognition of deamidated neoepitopes in CD

7: T cell recognition of neo-antigens in T1D

8: Prospects for diagnostic detection of neoepitope specific T cell responses

9: Conclusion

Chapter 5: Role of Th1 and Th2 in autoimmunity

Abstract

1: Introduction

2: Th1 and Th2 generation

3: Th1 and Th2 response in health

4: Breakdown of tolerance: Autoimmunity and allergy

5: Conclusion

Chapter 6: Role of Th17 cell in tissue inflammation and organ-specific autoimmunity

Abstract

Acknowledgments

1: Introduction

2: Differentiation of IL-17-producing Th17 cells

3: Amplification of Th17 cells

4: Stabilization of Th17 cells

5: Transcriptional regulation of Th17 cells

6: Regulators of Th17 cells

7: Small molecules inhibitor of Th17 cells

8: Role of Th17 cells in the pathogenesis of autoimmune diseases

9: Conclusion

Chapter 7: Peptide editing and its modulation in CD4+T cell tolerance to self

Abstract

1: Introduction

2: Cellular adaptive immunity in health and disease

3: Tolerance mechanisms: training lymphocytes for a proper self and non-self recognition

4: Peptide editing in the targets of organ-specific autoimmune diseases

5: Conclusion

Chapter 8: Innate lymphoid cells in autoimmune diseases

Abstract

1: Introduction

2: ILCs as crucial components of the mammalian immune system

3: ILCs in ADs

4: Conclusion

Chapter 9: Autoimmune diseases and the role of Toll-like receptor-7 and -9 signaling cascades

Abstract

1: Introduction

2: Toll-like receptors

3: Autoimmune disorders with a role for TLR7 or TLR9

4: Manipulation of TLR7 and TLR9-induced signaling

5: Conclusion

Chapter 10: The role of type III interferons in systemic autoimmune diseases

Abstract

1: Introduction

2: The type III interferon family

3: Production of type III interferons

4: Response of target cells to type III interferons

5: Potential association between interferons and autoimmunity

6: Type III interferons in systemic lupus erythematosus

7: Type III interferons in Sjögren syndrome

8: Type III interferons in rheumatoid arthritis

9: Type III interferons in antiphospholipid syndrome

10: Type III interferons in systemic sclerosis

11: Conclusion

Chapter 11: Regulation of immunological tolerance and human autoimmunity by NF-κB

Abstract

1: Introduction

2: Immunological tolerance

3: Monogenic NF-κB defects and human autoimmunity

4: Conclusion

Chapter 12: Micro RNA, circular RNA, neutrophils, and myeloperoxydases in autoimmune diseases

Abstract

1: Introduction

2: Micro ribonucleic acids (MicroRNAs)

3: Circular RNAs

4: Neutrophils

5: Myeloperoxidase in autoimmune diseases

6: Conclusion

Chapter 13: Human leukocyte antigen and autoimmunity

Abstract

1: Introduction

2: HLA genetic organization and protein structure

3: Autoimmune HLA disease association

4: Mechanisms involved in HLA-mediated autoimmune pathology

5: Conclusion

Chapter 14: HLA-G-mediated immunological tolerance and autoimmunity

Abstract

Acknowledgments

1: Introduction

2: Genetic variation of HLA-Ggene

3: Molecular structure of HLA-G

4: HLA-G expression regulation

5: HLA-G and receptor signaling pathways

6: HLA-G and autoimmunity

7: Implication of HLA-G-mediated immune tolerance in autoimmunity

8: Conclusion

Chapter 15: The immune system and the microbiota: The two sides of mucosal tolerance

Abstract

1: Introduction

2: Microbiota

3: Mucosal immune system

4: Mucosal tolerance

5: Mechanisms of mucosal tolerance toward commensal bacteria

6: Tolerance breaking at the mucous membranes and autoimmune diseases

7: Conclusion

Chapter 16: Role of free radicals in autoimmune diseases

Abstract

1: Introduction

2: Pathophysiology of free radicals

3: Inflammation and autoimmune diseases

4: Rheumatoid arthritis

5: Systemic lupus erythematosus

6: Conclusion

Chapter 17: Immunological tolerance and autoimmunity

Abstract

1: Introduction

2: Central tolerance of T cells and autoimmunity

3: Peripheral T cell tolerance and autoimmunity

4: Central B cell tolerance and autoimmunity

5: Peripheral B cell tolerance and autoimmunity

6: Conclusion

Chapter 18: Construction of bioscore for detection of self-tolerance failure: From analysis of silicosis cases

Abstract

1: Introduction

2: Effects of silica particles on human immune cells

3: Generating a bioscore/autoimmune score to detect early dysregulation of autoimmunity

4: Conclusion

Index