Gynecologic Oncology Handbook An Evidence Based Clinical Guide 3rd Edition by Michelle Benoit, M Yvette Williams Brown, Creighton Edwards ISBN 9780826155979 0826155979

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ISBN 10: 0826155979
ISBN 13: 9780826155979
Author: Michelle Benoit, M Yvette Williams Brown, Creighton Edwards

Known as the “blue book”, the Gynecologic Oncology Handbook: An Evidence-Based Clinical Guide is an invaluable resource for fellows, residents, and clinicians in the diagnosis and management of gynecologic cancers. Retaining the format and features that have made it a leading practical reference, this new edition has been thoroughly updated and reflects the latest advances in surgical techniques, chemotherapy protocols, breakthroughs in immunotherapies and targeted therapies, and much more.

The handbook covers the full scope of disease management in a concise and accessible format. Its compact size allows it to be easily taken with the busy practitioner on the ward or in the clinic. Clear illustrations that reinforce key concepts and essential algorithms for diagnostic techniques help clinicians to a quick and accurate diagnosis. Evidence-based practices for managing gynecologic cancers are emphasized throughout the handbook including for surgical care, and for all adjuvant therapies including chemotherapy, biologics, targeted therapies, immunotherapies, and combination radiation therapy. Detailed sections on survivorship care, palliative care, and management of reproductive function and other comorbid medical conditions round out the book’s comprehensive scope.

Its extensive coverage of current breakthroughs in treatment, references to critical clinical studies, and breakdown of directed gynecologic cancer workups and treatments make the Gynecologic Oncology Handbook, 3rd Edition a go-to resource within the field—including in preparation for the gynecologic oncology subspecialty certification oral board exam.

Key Features:

• Covers all fundamentals of gynecologic oncology including workup, AJCC and FIGO staging, surgical management, chemotherapy, targeted therapy, immunotherapy, and radiation therapy treatment, comorbidity diagnosis and management, and background study data
• Contains insight into recently approved immunotherapies for recurrent advanced and metastatic cervical and uterine disease
• Provides Gynecologic Oncology Referral Parameters, Performance Status Scales, Adverse Event Grading, RECIST evaluation criteria, chemotherapy protocols, statistics, and other useful formulas
• Includes clinical study references, medical comorbidity algorithms, directed workups, and treatment guidelines

Gynecologic Oncology Handbook An Evidence Based Clinical Guide 3rd Edition Table of contents:

1. Cancer Screening, Prevention, and Preinvasive Gynecologic Disease

Cervical Cancer Screening

The Human Papilloma Virus

Screening Recommendations

Management Guidelines

HPV Vaccination

Preinvasive Disease

Cervical SILs

AIS

Vulvar SILs

Notable studies

Vaginal Squamous Intraepithelial Neoplasia

SILs and HIV

Uterine Precancer/Endometrial Intraepithelial Neoplasia

Serous Tubal Intraepithelial Carcinoma

Tubo-Ovarian Cancer Screening

Screening Test

CA-125

HE4

Risk of Malignancy Index

Morphology Index

Risk of Ovarian Malignancy Algorithm

Risk of Ovarian Cancer Algorithm

Copenhagen Index

OVA-1 Test

Ovarian Cancer Symptom Index

The UKCTOCS

The PLCO Trial

Japan Screening Study

Serial US of Ovarian Abnormalities

Serial USS for Those With a Family History of OC

GOG 199

Opportunistic Salpingectomy in Low-Risk Women

OC Risk

Changing CA-125 “Normals”

Screening Pelvic Examination in Adult Women

2. Gynecologic Cancers

Cervical Cancer

Characteristics

Pretreatment Workup

Histology

Staging

Treatment Options by Stage

Surgical Treatment

XRT

Adjuvant Posthysterectomy Treatment

Advanced Disease

Recurrent Disease

Survival

Prognostic Factors for Survival

Follow-Up

Neuroendocrine Tumors

Notable Trials in Cervical Cancer

Tubo-Ovarian Cancers: Ovarian, Fallopian Tube, and Primary Peritoneal Cancers

Characteristics

Pretreatment Workup

Treatment

Histology

Staging

Epithelial Tubo-Ovarian Cancer

Histology

Staging

Treatment

Treatment by Stage

Predictive Models for Optimal Surgical Cytoreduction

Genetic Testing

Chemotherapy for Epithelial Tubo-OC

Second Look Laparotomy

Recurrence

Secondary Cytoreduction Surgery

PARP Inhibitors and AML/MDS

Cerebellar Degeneration

Survival

Survival Care

Epithelial TOC Notable Trials

HIPEC/IDS Studies

Low Malignant Potential Ovarian Tumors: Borderline Tumors

Staging

Treatment

Recurrence

Survival

Fallopian Tube Cancer

Histology

Staging

Treatment

Survival

Primary Peritoneal Cancer

Germ Cell Tumors

Staging

Treatment

Recurrence

Follow-Up

Histologic Subtypes and Directed Therapies

GCT Trials

Sex Cord Stromal Tumors

Staging

Treatment

Histology

5YS

Sex Cord Stromal Tumor Trials

Uterine Cancer

Characteristics

Prognostic Factors

Pretreatment Workup

Categorical Divisions

Staging

Treatment

Overview

Recurrence

Fertility-Sparing Options

Postoperative Hormone Replacement Therapy

Synchronous Ovarian Neoplasm

Survival

Follow-Up

Tamoxifen and Uterine Cancer

Notable Studies in Uterine Cancer

Uterine Sarcomas

Leiomyosarcoma

Targeted, Biologic, and Immunotherapies

Notable Studies in Sarcoma

Vulvar Cancer

Characteristics

Histology

Pretreatment Workup

Staging

Treatment

Recurrence

Survival

Follow-Up

Notable Trials

Vaginal Cancer

Characteristics

Pretreatment Workup

Histology

Staging

Treatment

Recurrent Disease

Survival

Follow-Up

Gestational Trophoblastic Disease

Characteristics

Histopathology

Diagnosis

Pretreatment Workup

Serum hCG

Staging

Treatment

Duration of Chemotherapy

Management of Acute Disease and Induced Complications

Resistant Disease

Recurrent Disease

Follow-Up

Notable Trials

3. Hereditary Cancer Syndromes

Hereditary Cancers

Epithelial Ovarian Cancer

Breast Cancer

Heredity Nonpolyposis Colon Cancer/Lynch Syndrome

Li-Fraumeni Syndrome

Cowden Syndrome/PTEN Harmatoma Syndrome (CS/PHTS)

Peutz Jeghers Syndrome

Effectiveness of Screening and Risk-Reduction Recommendations

4. Surgical Care for Gynecologic Cancers

Anatomy

Layers of the Abdomen

Ligaments

Vasculature

Nerves

Vulvar and Groin Anatomy

Lymph Nodes

Potential Spaces in the Pelvis

Preoperative Risk Assessment and Optimization

Recommended Laboratories

Bowel Preparation

American Society of Anesthesiologists Score

Cardiac Risk Score

Functional Status

Frailty Index

Subacute Bacterial Endocarditis

DVT/VTE Prophylaxis

Surgical Bundling

Comorbidity Indices

Surgical Procedures

Laparotomy Incisions

Incision Closure

Lymph Node Dissection

Bowel Diversion

Bowel Resection

Urinary Diversion: Stents, Conduits, and Bladder Reconstructions

Reconstructive Surgery

Splenectomy

Diaphragmatic Stripping

Minimally Invasive Surgery

Surgical Devices

Drains

Central Venous Catheters

Peritoneal Catheters

Catheter Troubleshooting

Instruments

Staplers

Suture

Intraoperative Complications

Vascular Injury

Nerve Injury

GI Injury

Urinary Tract Injury

Intraoperative Hemorrhage

Postoperative Care Protocols

Radical Vulvar Surgery

Radical Hysterectomy

Urinary Conduits and Pelvic Exenteration

Bowel Resection

Ovarian Cancer Debulking

Enhanced Recovery Pathways

Enhanced Recovery After Surgery

Opiates

Postoperative Complications

GI Complications

Hemorrhage

Postoperative Fever

Wound Infection

Urinary Tract Injury

Lymphatic Complications

Nerve Injury

Perioperative Management of Medical Comorbidities

Enhanced Recovery Pathways in Gynecologic Oncology

Vascular Thromboembolism

Nutrition

Endocrine Management

Hepatic Disease

Neurologic Disease

Alcohol Withdrawal

Blood Transfusion

Critical Care

Pulmonary Complications

Cardiac Complications

Shock and Sepsis

Febrile Neutropenia

Renal Complications

Acid–Base Disorders

Electrolyte Abnormalities

Fluids and Blood Products

Electrolytes

Neurologic Care

Risk Stratification of Morbidity and Mortality

5. Gynecologic Cancer Systemic Treatment Modalities

Chemotherapy

One Letter and Combination Chemotherapy Abbreviations

Chemotherapy Definitions

Delivery

Metabolism

Principles of Chemotherapy Tumor Kill

Chemotherapy Regimens

Platinum Sensitivity/Resistance in HGSTOC or Ovarian GCTs

Toxicity

The Cell Cycle

Growth Fraction

Cell Death

Log Kill

Cell-Cycle Nonspecific Chemotherapeutic Agents

Cell-Cycle Specific Agents

Cell Growth

Mechanisms of Cytotoxicity

Mechanisms of Resistance

Prior to Chemotherapy Administration

Classes of Chemotherapeutic Agents and Independent Mechanisms of Action of Alkylating Agents

Antitumor Antibiotics

Antimetabolites

Plant Alkaloids

Hormonal Agents

Novel Drugs

Protective Agents

Antiangiogenesis, Targeted Therapies, and Immunotherapy

Treatment of Extravasation Injury

Neutropenic Fever

Vaccinations in Cancer Patients

XRT

Radiation Types

Definitions

Radiation Effects

Energy Equivalences

Radiation Delivery

Tumoricidal Basics

The Four Rs of Radiation

Disease-Site Radiation Treatment

Design of External Beam Radiation Fields

Radiation Effects

Cervical Cancer and XRT Delivery Time

6. Reproductive Function, Sexuality, and Pregnancy With Gynecologic Cancer

Sexual Function, Fertility, and Cancer

Sexual Dysfunction

Ovarian Protection During Chemotherapy

Fertility Preservation

XRT and Fertility

Cancer in Pregnancy

XRT in Pregnancy

Chemotherapy in Pregnancy

Surgical Management in Pregnancy

Cervical Cancer in Pregnancy

Ovarian Neoplasms in Pregnancy

Other Gynecologic Cancers in Pregnancy

7. Survivorship Care for Gynecologic Malignancies

Surveillance Recommendations

Surveillance Guidelines

Uterine Cancer

Ovarian and Tubal Cancer

Cervical Cancer, Vulvar, and Vaginal Cancer

Melanoma Patients

Survivorship Guidelines

Hormone Replacement

8. Palliative Care

Palliative Care Pathways

Palliative Care

Hospice

End-of-Life Discussion

Multidisciplinary Approach

Communication

Delivering Bad News

Management of Specific Symptoms

Active Dying (Transitioning)

Ethical Issues

Notable Studies

9. Statistics and Reference Material

Statistics

Definitions

Methods Used to Analyze Data

Receiver Operating Characteristic

Endpoints of a Study

Phases of Trials

Randomization Techniques

Eligibility Criteria

Bias and Confounding

Trial Safety, Review, and Ethics

Types of Trials

Trial Evaluation

Survival Analysis

Causality

WHO Screening Guidelines

Parametric Versus Nonparametric Testing

To Quantify Associations

Means of Magnitude

Univariate Versus Multivariate Testing

Surrogate Endpoints

ICER

Reference Material

Surveillance Visit Checklist: Checklist for Surveillance of Gynecologic Malignancies

Gynecologic Oncology Referral Parameters

Performance Status Scales

Adverse Event Grading

Confirmation of Response

Common Chemotherapy Protocols and Dosing

Abbreviations

Index

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Tags: Michelle Benoit, M Yvette Williams Brown, Creighton Edwards, Gynecologic Oncology, Clinical Guide