Biology of Vascular Smooth Muscle Vasoconstriction and Dilatation 2nd Edition by Yuansheng Gao ISBN 9811971218 978-9811971211

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ISBN 10: 9811971218
ISBN 13: 978-9811971211
Author: Yuansheng Gao

This book provides a concise yet comprehensive review of the morphological, biochemical, electrical, mechanical, and metabolic properties of vascular smooth muscle, the regulation of vascular activities and the intracellular signaling involved. It particularly focuses on newly identified vasoactive agents, enzymes and transduction mechanisms. It also discusses the latest findings in the regulation of cerebral, coronary and pulmonary circulation as well as vascular activity under hypoxia and ageing. The second edition intends to update the contents of the first edition with the latest achievements in the regulation of vascular activities from biochemical, structural, genetic, physiological, and pharmacological aspects. In addition, two new chapters related to microRNA and extracellular vesicles have been added to reflect their newly discovered important roles in vascular activities.

The contraction and dilatation activities of vasculature are of fundamental importancefor maintaining circulation homeostasis and adapting to physiological changes. Over the last four decades, there have been significant advances in our understanding of the biochemical, structural, genetic, physiological, and pharmacological aspects of vascular activity regulation, and these insights into the responsiveness of blood vessels under normal and pathophysiological conditions help to provide valuable weapons in the fight vascular diseases. The book is of interest to researchers and graduate students, both in basic research and in clinic settings, in the field of vascular biology.

Biology of Vascular Smooth Muscle Vasoconstriction and Dilatation 2nd  Table of contents:

Part I. General Properties of Vasculature

1. Architecture of the Blood Vessels

2. Ultrastructure of Vascular Smooth Muscle

3. Vascular Endothelium

4. Electrical and Mechanical Properties of Vascular Smooth Muscle

5. Biochemistry of the Contractile Proteins of Smooth Muscle

6. Metabolism of Vascular Smooth Muscle

Part II. Regulators of Vasoreactivity

7. Neurotransmitters

8. Endothelium-Derived Factors

9. Local Metabolic Factors and Vasoactivity

10. Shear Stress, Myogenic Response, and Blood Flow Autoregulation

Part III. Intracellular Signalings

11. Intracellular Ca2+ Regulation

12. Regulation of Myosin Light Chain Phosphorylation

13. Cyclic AMP Signaling

14. Cyclic GMP Signaling

15. MicroRNAs and Vascular Activity

16. Extracellular Vesicles and Vascular Activity

Part IV. Heterogeneity in Vasoreactivity

17. Coronary Vasoreactivity

18. Cerebral Vasoreactivity

19. Pulmonary Vasoreactivity

20. Hypoxic Vasoreactivity

21. Ageing and Vasoreactivity

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Tags: Yuansheng Gao, Vascular Smooth, Muscle Vasoconstriction