Contemporary Management of Metastatic Colorectal Cancer A Precision Medicine Approach 1st Edition by Aslam Ejaz, Timothy Pawlik ISBN 0323985688 9780323985680

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Product details:

ISBN 10: 0323985688

ISBN 13: 9780323985680

Author:  Aslam Ejaz, Timothy M. Pawlik 

Contemporary Management of Metastatic Colorectal Cancer: A Precision Medicine Approach 1st Edition: Contemporary Management of Metastatic Colorectal Cancer: A Precision Medicine Approach summarizes current knowledge and provides evidenced-based practice recommendations on how to treat patients with metastatic colorectal cancer. The book presents topics such as pre-operating imaging, the use of molecular markers in treatment decisions, neoadjuvant therapy, synchronous colorectal liver metastasis, and minimally invasive approaches. In addition, it discusses immunotherapy, targeted therapies and survivorship. This is a valuable resource for practitioners, cancer researchers, oncologists, graduate students and members of biomedical research who need to understand more about novel treatments for colorectal cancer metastasis.

• Summarizes contemporary data in the workup and treatment of patients with metastatic colorectal cancer
• Discusses novel patient-centric personalized approaches surrounding the management of such cancer types
• Presents evidenced-based recommendations for precision care among patients with metastatic colorectal cancer

 

Contemporary Management of Metastatic Colorectal Cancer: A Precision Medicine Approach 1st Edition Table of contents:

Chapter 1 Epidemiology and risk factors for metastatic colorectal disease

• Colorectal cancer incidence and survival
• Summary
• References

Chapter 2 The tumor microenvironment of colorectal cancer liver metastases: Molecular mediators and future therapeutic targets

• Introduction
• The unique immune microenvironment of the liver
• The extracellular matrix regulates cancer cell survival and growth in the liver
• Potential strategies for targeting the microenvironment of CRLM and increasing immunotherapy efficacy in patients with liver metastatic disease
• Conclusion
• Acknowledgements
• References

Chapter 3 Pre-operative imaging, response evaluation, and surgical planning – CT, PET, radiomics, and FLR measurement

• Introduction
• Role of imaging in CRLM
• Pre-operative imaging of CRLMs
• Assessment of prognosis and surgical candidacy
• Use of imaging for surgical planning
• Pre-operative treatment and response evaluation of CRLM
• Increasing future remnant liver volume and volumetric assessment
• Alternative therapies for CRLM
• Conclusion
• Reference

Chapter 4 Use of molecular markers and other personalized factors in treatment decisions for metastatic colorectal cancer

• Introduction
• Prognostic versus predictive
• Disease characteristics
• Histology
• Pharmacogenetics for conventional cytotoxic chemotherapy
• KRAS
• BRAF
• HER2
• DNA microsatellite instability and immunotherapy
• Tumor sidedness
• Circulating tumor cells and cell free DNA
• Gut microbiome
• Conclusions
• References

Chapter 5 Role of Neoadjuvant therapy in the treatment of patients with colorectal liver metastases

• Introduction
• Rationale for perioperative chemotherapy for colorectal liver metastases
• Preoperative chemotherapy for patients with unresectable liver metastases
• Neoadjuvant chemotherapy for resectable liver metastases
• Safety of neoadjuvant chemotherapy for colorectal liver metastases
• Conclusions
• References

Chapter 6 Management of the disappeared colorectal liver metastasis

• Introduction
• Defining disappearing colorectal liver metastasis (DLM)
• Predictors of DLM pathologic response
• Intra-Operative evaluation of DLM
• Surgical resection versus surveillance of DLM
• Summary
• References

Chapter 7 Approach to small liver remnant – strategies to increase resectability

• Introduction
• Future liver remnant (FLR)
• Portal vein embolization (PVE)
• Combined portal vein & hepatic vein embolization
• Associating liver partition and portal vein ligation
• Conclusion
• References

Chapter 8 Two-stage versus ALPPS for large intrahepatic burden of colorectal liver metastasis

• FLR hypertrophy and feasibility to complete both stages
• Morbidity and Mortality
• Oncological results
• Conclusion
• References

Chapter 9 Synchronous colorectal liver metastasis – simultaneous vs. staged approach

• Introduction
• Sequencing of care for sCRLM
• Surgical approach summary
• MSK approach
• Case-based learning
• References

Chapter 10 Minimally invasive approaches to colorectal liver metastases

• Introduction
• Laparoscopic liver resection
• Robotic liver resection
• Laparoscopic radiofrequency ablation
• Laparoscopic microwave coagulation
• Conclusion
• References

Chapter 11 Hepatic resection of colorectal liver metastasis in the presence of extrahepatic disease

• Incidence of extrahepatic disease
• Diagnosis of extrahepatic disease
• Role of surgery in patients with extrahepatic disease
• Recurrence
• Lung metastases
• Lymph node metastases
• Peritoneal metastases
• Conclusions
• References

Chapter 12 Locoregional approaches to colorectal liver metastasis – ablation

• Introduction
• Indications and contraindications
• Radiofrequency vs microwave ablations
• Ablation approaches
• Post-ablation complications
• Surveillance
• Local recurrence rates
• Long-term outcomes
• Long-term outcomes of the multi-modality treatments
• Summary points
• Disclosure statement
• References

Chapter 13 Locoregional approaches to colorectal liver metastasis – intra-arterial

• Introduction
• Embolic therapies
• Transarterial radioembolization (TARE)
• Hepatic artery infusion chemotherapy (HAIC)
• Conclusions
• Case stem
• References

Chapter 14 Locoregional Approaches to Colorectal Liver Metastasis – Radiation Options

• Introduction: external beam radiation therapy (EBRT) for colorectal liver metastases
• External beam radiation: rationale for ablative dosing
• External beam radiation: patient selection
• External beam radiation: treatment planning considerations
• External beam radiation: target volume design and treatment objectives
• External beam radiation: outcomes and surveillance considerations
• Future directions
• References

Chapter 15 Immunotherapy and targeted therapies for colorectal liver metastasis

• Targeted therapy in CRC with CLM
• Resectable CLM at diagnosis with no extra-hepatic metastatic disease
• Unresectable CLM at diagnosis with a potential for resection with no extra-hepatic metastatic disease
• CLM with no potential for resection and/or unresectable extra-hepatic disease
• Immunotherapy
• References

Chapter 16 Adjuvant therapy following resection of colorectal liver metastases

• Introduction
• Timing of systemic treatment
• Role of adjuvant treatment
• Adjuvant intra-arterial chemotherapy following resection of colorectal liver metastases
• Conclusion
• Clinical case
• References

Chapter 17 Long-term prognosis and surveillance of patients with resected colorectal liver metastasis

• Introduction
• Clinical risk scores
• Other prognostic tools
• Inflammatory and immune predictors of survival
• Predicting recurrence
• Surveillance and recurrence
• Conclusion
• References

Chapter 18 Management of secondary recurrence of intra-hepatic colorectal liver metastasis following initial hepatic resection

• Introduction
• Surveillance following initial hepatectomy
• Repeat liver resection
• Other treatment modalities
• References

Chapter 19 Colorectal liver metastasis: survivorship

• Introduction
• What is a cancer survivor?
• Colorectal cancer survivors with liver metastases
• Surveillance for recurrence and screening for second primary cancers
• Assessment and management of physical and psychosocial effects of colorectal cancer and treatment
• Routine health promotion needs
• Coordination of care among specialists and primary care clinicians
• Limitations and future directions

 

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