DeGroot Endocrinology 8th Edition by Paul Robertson 9780323694148 0323694144

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ISBN 10: 0323694144
ISBN 13: 9780323694148 
Author:  Paul Robertson

Thoroughly updated to reflect today’s recent advances in adult and pediatric endocrinology, DeGroot’s Endocrinology, 8th Edition, remains the comprehensive, international reference of choice for today’s endocrinologists and fellows. A full peer review of the previous edition, conducted by a largely new group of renowned editors, was used to update this trusted, two-volume resource. In-depth coverage of both basic and clinical aspects of endocrinology and up-to-date information on the treatment and management of endocrine disorders are provided by a diverse group of expert contributors from six continents. A full-color format and helpful algorithms summarize clinical decision-making and practical approaches to patient management.

DeGroot Endocrinology 8th Table of contents:

Part 1. Principles of Endocrinology and Hormone Signaling

1. Principles of Endocrinology

   • Definition and Scope of Endocrinology
   • Historical Perspectives
   • Principles of Hormone Action
   • Hormone Action Through Receptors
   • Role of the Clinical Endocrinologist
   • Major Unsolved Problems

2. Principles of Endocrine Measurements

   • Introduction and Brief History of Endocrine Assays
   • Overview of General Concepts
   • Competitive Binding Assays
   • Noncompetitive Immunoassays
   • Free Serum/Plasma Hormone Assays
   • Plasma Renin Assays
   • Structural Assays––Mass Spectrometry
   • Summary and Future Directions

3. Endocrine Rhythms, the Sleep-Wake Cycle, and Biological Clocks

   • Introduction
   • Endocrine Rhythms
   • Cell Clocks
   • The Sleep-Wake Cycle
   • Melatonin as the Biological Marker of the Night
   • Consequences of Rhythm Disturbance on Metabolic Health
   • Novel Technology for the Study of Biological Rhythms
   • Summary
   • Conclusions

Part 2. Neuroendocrinology and Pituitary Disease
4. Prolactinomas and Disorders of Prolactin Secretion

• History
• Epidemiology
• Pathogenesis
• Pathology
• Differential Diagnosis of Hyperprolactinemia
• Diagnosis of Prolactinomas
• Treatment

5. Hypopituitarism Including Growth Hormone Deficiency

   • History
   • Etiology of Hypopituitarism
   • Morbidity and Mortality
   • Clinical Features
   • Diagnosis and Endocrine Evaluation
   • Hormone Replacement Therapy
   • Pregnancy
   • Patient Care–Multidisciplinary Approach and Patient Education

6. Acromegaly

   • Pathogenesis
   • Diagnosis
   • Management
   • Integrated Treatment Approach to the Management of Acromegaly

…

Part 3. Obesity and Nutrition
19. Basic and Clinical Appetite Regulation and Energy Expenditure

• Introduction
• Components of Eating Behavior
• Components of Energy Expenditure
• Body Weight Regulation
• Conclusions

20. Obesity: Risk, Risk Factors, and Medical Management

• Prevalence of Overweight and Obesity
• Social and Environmental Contributions to Obesity
• Diseases Associated With Obesity
• Therapy for Obesity

…

Part 4. Diabetes Mellitus
28. Development of the Endocrine Pancreas

• Pancreas Morphogenesis
• Early Organ Specification and Bud Formation
• Cell Type Differentiation
• The Role Of Pancreatic Development In Human Diabetes

29. Regulation of Islet Hormone Synthesis and Secretion

• Introduction
• Hormonal Synthesis
• Hormonal Secretion and Action

…

Part 5. Parathyroid Gland, Calciotropic Hormones, and Bone Metabolism
47. Parathyroid Hormone and the Parathyroid Hormone Receptor Type 1 in the Regulation of Calcium and Phosphate Homeostasis and Bone Metabolism

• Regulation Of Mineral Ion Homeostasis—General Considerations
• Parathyroid Hormone
• Parathyroid Hormone–Dependent Regulation Of Mineral Ion Homeostasis Mediated Through The Parathyroid Hormone Receptor Type-1
• Molecular Properties Of The Parathyroid Hormone Receptor Type-1
• The Parathyroid Hormone Receptor Type-2 And Tip39
• Summary

48. Parathyroid Hormone-Related Protein

• The PTHrP Gene And The PTH/PTHrP Gene Family
• Posttranslational Processing Of Parathyroid Hormone-Related Protein
• Parathyroid Hormone-Related Protein Receptors
• Nuclear Parathyroid Hormone-Related Protein
• Physiologic Functions Of Parathyroid Hormone-Related Protein
• Parathyroid Hormone-Related Protein In Disease
• Conclusion

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