Environmental Endocrinology and Endocrine Disruptors Endocrine and Endocrine targeted Actions and Related Human Diseases 1st Edition by Rosario Pivonello, Evanthia Diamanti Kandarakis ISBN 3030390438 ‎ 978-3030390433

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ISBN 10:  3030390438

ISBN 13: ‎ 978-3030390433

Author: Rosario Pivonello,  Evanthia Diamanti Kandarakis

This book describes how exposure to various classes of endocrine disruptors, as well as other environmental chemicals targeting the endocrine system by alternative non-endocrine mechanisms, impact on endocrinological and endocrinological-related diseases. It includes comprehensive reviews of all aspects of environmental endocrinology, ranging from sources and patterns of exposure and identification of endocrine targets to direct endocrine disruptive mechanisms and indirect actions on the endocrine system, the latter including endocrine cell-directed cytotoxicity, oxidative damage, and genetic and epigenetic aberrations resulting in endocrine damage. It also examines the causal pathways and offers an extensive overview of downstream endocrinological and endocrinological-related disorders. In addition, several chapters focus on transgenerational actions, which are a topic of particular interest. Lastly, evidence from preclinical and clinical studies provides the basis for an in-depth, critical discussion of each topic. The book is part of the SpringerReference program, which provides access to ‘living editions’ that are constantly updated using a dynamic peer-review publishing process.

Environmental Endocrinology and Endocrine Disruptors: Endocrine and Endocrine-targeted Actions and Related Human Diseases 1st Table of contents: 

• Introduction to Environmental Endocrinology

  • Definition and scope of environmental endocrinology
  • Overview of the endocrine system
  • Mechanisms of endocrine disruption

• Endocrine Disruptors: Sources and Exposure

  • Chemical endocrine disruptors (e.g., pesticides, plastics)
  • Non-chemical endocrine disruptors (e.g., radiation, stress)
  • Routes of exposure and environmental pathways

• Mechanisms of Endocrine Disruption

  • Molecular mechanisms (e.g., receptor binding, gene expression)
  • Interactions with hormone signaling pathways
  • Effects on endocrine glands (e.g., thyroid, gonads)

• Endocrine-targeted Actions

  • Disruption of reproductive health (fertility, development)
  • Effects on thyroid function and metabolism
  • Impact on neuroendocrine systems

• Endocrine Disruption and Human Diseases

  • Reproductive and developmental disorders
  • Metabolic diseases (e.g., obesity, diabetes)
  • Cancer (e.g., breast, prostate, and thyroid cancers)
  • Neurodevelopmental disorders

• Environmental Exposures and Vulnerable Populations

  • Susceptibility across life stages (e.g., prenatal, childhood, aging)
  • Gender differences in endocrine disruption
  • Environmental justice and disproportionate risks

• Regulation and Risk Assessment

  • Regulatory frameworks for endocrine disruptors (e.g., EPA, EU)
  • Risk assessment methods for endocrine disruption
  • Policy and public health implications

• Mitigation Strategies and Future Directions

  • Reducing exposure to endocrine disruptors
  • Advances in research and toxicology
  • Future challenges and emerging contaminants

• Conclusions

  • Summary of key findings
  • The need for continued research and policy development

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