Handbook of Pharmacokinetics and Toxicokinetics by Mehdi Boroujerdi 9781000878479 1000878473

Handbook of Pharmacokinetics and Toxicokinetics Mehdi Boroujerdi – Ebook Instant Download/Delivery ISBN(s): 9781032197050, 9781032197470, 9781003260660, 1032197056, 1032197471, 1003260667, 9781000878479, 1000878473

Product details:

• ISBN 10: 1000878473
• ISBN 13: 9781000878479
• Author:  Mehdi Boroujerdi

This fully revised and expanded volume is an effort to blend the common approaches to pharmacokinetics and toxicokinetics. It integrates the principles held in common by both fields through a logical and systematic approach, which includes mathematical descriptions of physical and physiological processes employed in the approaches to pharmacokinetics and toxicokinetics modeling. It emphasizes general principles and concepts and related, isolated applications and case study observations. The systematic compilation of mathematical concepts and methodologies allows readers to decide on relevant concepts and approaches for their research, scientific or regulatory decisions, or for offering advanced courses/workshops and seminars. Features: Comprehensive handbook on principles and applications of PK/TK appealing to a diverse audience including scientists and students An excellent text fully revised and fully updated for anyone interested in the theoretical and practical pharmacokinetics The systematic compilation of mathematical concepts and methodologies allows readers to decide on relevant concepts and approaches for their research Incorporates research relevant to SDGs and of interest to industrial and regulatory environmental scientists involved in chemical contamination research and regulatory decision making related to soil, water, and ocean Includes sections on applications and case studies

Table contents:

1 Pharmacokinetics and Toxicokinetics

2 PK/TK Considerations of Auricular (Otic) – Buccal/Sublingual, and Ocular/Ophthalmic Routes of Administration

3 PK-TK Considerations of Nasal, Pulmonary and Oral Routes of Administration

4 PK/TK Considerations of Intra-Arterial, Intramuscular, Intraperitoneal, Intravenous, and Subcutaneous Routes of Administration

5 PK/TK Considerations of Transdermal, Intradermal, and Intraepidermal Routes of Administration

6 PK/TK Considerations of Rectal, Vaginal, and Intraovarian Routes of Administration

7 PK/TK Considerations of Absorption Mechanisms and Rate Equations

8 PK – TK Considerations of Distribution Mechanisms and Rate Equations

9 PK/TK Considerations of Xenobiotic Metabolism Mechanisms and Rate Equations

10 PK – TK Considerations of Renal Function and Elimination of Xenobiotics – Estimation of Parameters and Constants

11 Elimination Rates and Clearances (Excretion + Metabolism)

12 Approaches in PK/PD and TK/TD Mathematical Modeling

13 Practical Applications of PK/TK Models: Instantaneous Exposure to Xenobiotics – Single Intravenous Bolus Injection

14 Practical Applications of PK/TK Models: Continuous Zero‑Order Exposure to Xenobiotics – Intravenous Infusion

15 Practical Applications of PK/TK Model: First-Order Absorption via Extravascular Route – Oral Administration

16 Practical Application of PK/TK Models: Multiple Dosing Kinetics

17 Biopharmaceutics Provisions, Classifications and Mechanistic Models

18 Bioavailability, Bioequivalence, and Biosimilarity

19 Quantitative Cross-Species Extrapolation and Low-Dose Extrapolation

20 Practical Application of PK/TK Models: Population Pharmacokinetics/Toxicokinetics

21 Practical Application of Pk/TK Models: Preclinical PK/TK and Clinical Trial

22 Adjustment of Dosage Regimen in: Renal Impairment, Liver disease and Pregnancy

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