Neurological Complications of Systemic Cancer and Antineoplastic Therapy 2nd Edition by Herbert B Newton, Mark G Malkin ISBN 9780128219768 0128219769

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Product details:
ISBN 10: 0128219769
ISBN 13: 9780128219768
Author: Herbert B Newton, Mark G Malkin

Neurological Complications of Systematic Cancer and Antineoplastic Therapy, Second Edition provides an expanded, updated and in-depth review of common manifestations related to neurology that occur in patients with systemic cancer. These include brain metastases, spinal cord compression, cerebrovascular events, and leptomeningeal disease. The book also discusses neurological complications related to treatments such as radiation and chemotherapy and is an essential reference for the practicing neurologist and oncologist.

Sections in this new release cover the pathophysiology and molecular biology of cancer and the metastatic phenotype, Metastatic spread to cranial and peripheral nerves and brachial and lumbosacral plexuses, Metabolic and nutritional disorders, CNS infections, Neurological complications of immunotherapy and bone marrow transplants, Neurological complications of new molecular agents and immuno-modulatory drugs, and more.

• Summarizes the neurologic effects of both cancer and cancer treatment
• Provides scientific and clinical information relevant to research and treatment
• Identifies neurological complications by tumor type and tumor therapy
• Covers GI, lung, breast, gynecological, head and neck cancers, and more
• Includes radiotherapy, chemotherapy, immunotherapy, and new drugs
• Contains melanoma, lymphoma, sarcoma, myeloma, leukemia, and more

Neurological Complications of Systemic Cancer and Antineoplastic Therapy 2nd Edition Table of contents:

Section I: Metastatic neurological complications

Chapter 1: Common symptoms at presentation of nervous system metastases

Abstract

1: Introduction

2: Brain metastases

3: Leptomeningeal disease

4: Spinal cord metastases

5: Epidural spinal cord metastases/epidural spinal cord compression

6: Cauda equina syndrome

7: Neoplastic and radiation plexopathy

8: Conclusion

References

Chapter 2: Neuroimaging of systemic metastatic disease

Abstract

Acknowledgment

1: Technical considerations

2: Anatomic locations

3: Intracranial complications of systemic disease

References

Chapter 3: Nonimaging evaluation of patients with nervous system metastases

Abstract

Disclosures

1: Introduction

2: Electroencephalography

3: Evoked potentials

4: Electromyography and nerve conduction studies

5: Nerve biopsy

6: Cerebrospinal fluid

7: Conclusion

References

Chapter 4: Biology and pathophysiology of central nervous system metastases

Abstract

1: Introduction

2: Molecular biology of neoplasms

3: Mechanisms of brain metastasis

4: Biological mechanisms of the metastatic cascade

5: Blood–brain barrier

6: Genetics of metastases

7: Conclusion

Disclosure

References

Chapter 5: Intracranial metastases

Abstract

1: Introduction and epidemiology

2: Pathology

3: Clinical presentation

4: Neuroimaging

5: Surgical therapy

6: Radiation therapy

7: Chemotherapy

References

Further reading

Chapter 6: Neurosurgical approaches to the treatment of intracranial metastases

Abstract

1: Background

2: Initial approach

3: Tumor resection

4: Surgical adjuncts

5: Other neurosurgical techniques

6: Management of recurrence—When to repeat resection

7: Management of CNS metastases in uncommon locations

8: Conclusion

Disclosures

References

Chapter 7: Epidural metastasis and spinal cord compression

Abstract

1: Introduction

2: Epidemiology

3: Pathophysiology

4: Clinical presentation

5: Diagnosis

6: Prognosis

7: Treatment

8: Conclusion

References

Chapter 8: Leptomeningeal metastasis

Abstract

1: Introduction

2: Prognosis

3: Anatomy

4: Pathogenesis

5: Clinical presentation

6: Diagnostic studies/staging

7: Treatment

8: Summary

References

Chapter 9: Cranial nerve involvement by metastatic cancer

Abstract

1: Introduction

2: Clinical presentation of cranial nerve involvement

3: Typical imaging findings of cranial nerve involvement

4: Cancers of special interest

5: Summary

References

Chapter 10: Cancer-related plexopathies

Abstract

1: Introduction

2: Review of plexus anatomy

3: Plexopathy

4: Diagnosis of plexopathy in patients with cancer

5: Diagnostic studies

6: Cancers of special interest

7: Supportive treatment of cancer-related plexopathy

8: Summary

References

Section II: Nonmetastatic neurological complications

Chapter 11: Cerebrovascular complications of malignancy

Abstract

1: Epidemiology of cerebrovascular disease in malignancy

2: Direct tumor effects and intracranial hemorrhage

3: Direct tumor effects and cerebral infarction

4: Coagulation disorders

5: Cancer-related infectious disease and stroke: Septic cerebral infarction

6: Infectious vasculitis

7: Complications of cancer treatment

8: Conclusion

References

Chapter 12: Metabolic and nutritional nervous system dysfunction in cancer patients

Abstract

1: Introduction

2: Metabolic and toxic encephalopathy

3: Tumor lysis syndrome

4: Cancer anorexia-cachexia syndrome

5: Nutritional myelopathy

6: Peripheral neuropathy

7: Nutritional and toxic myopathy

8: Immunotherapy side effects

9: CAR-T cell complications

References

Chapter 13: Central nervous system infections in cancer patients

Abstract

1: Introduction

2: Approach to cancer patients with suspected CNS infection

3: High-risk patient groups

4: Management of common CNS infections

5: Vaccine-preventable infections: The COVID-19 pandemic and cancer patients

6: Conclusions

References

Chapter 14: Diagnosis and treatment of paraneoplastic neurological disorders

Abstract

1: Introduction

2: Pathogenesis

3: Clinical diagnosis

4: Antineuronal antibodies

5: Treatment

6: Underlying malignancy

7: Paraneoplastic disorders and immune checkpoint inhibitors

8: Paraneoplastic neurological disorders

9: Conclusion

References

Section III: Neurological complications of specific neoplasms

Chapter 15: Neurological complications of lung cancer

Abstract

1: Introduction

2: Direct complications of lung cancer

3: Indirect complications of lung cancer

References

Chapter 16: Neurological complications of breast cancer

Abstract

1: Introduction

2: Metastatic complications

3: Nonmetastatic complications

4: Regional approach to the diagnosis of neurological symptoms

5: Conclusion

References

Chapter 17: Neurological complications of melanoma

Abstract

1: Introduction

2: Neurological complications of malignant melanoma

3: Neurological complications of noncutaneous melanomas

References

Chapter 18: Neurological complications of lymphoma

Abstract

1: Introduction

2: Intracranial metastases

3: Spinal cord processes

4: Peripheral nervous system disease

5: Paraneoplastic neurological syndromes

References

Chapter 19: Neurologic complications of the leukemias

Abstract

1: Introduction

2: Diagnostic considerations

3: The acute leukemias

4: The chronic leukemias

5: Conclusion

References

Chapter 20: Neurological complications of systemic cancer of the head and neck

Abstract

1: Introduction

2: Local and locoregional complications

3: Distant metastases

4: Leptomeningeal carcinomatosis

5: Medical therapy

6: Syncope in patients with head and neck cancer

References

Further reading

Chapter 21: Neurological complications of gynecological cancers

Abstract

1: Introduction

2: Local/regional spread of gynecological cancers to the lumbosacral plexus

3: Distant CNS metastases from gynecological cancers

4: Paraneoplastic syndromes due to gynecological cancers

5: Neurological complications associated with treatment of gynecological cancers

6: Conclusion

References

Chapter 22: Neurological complications of GI cancers

Abstract

Permissions summary

1: Overview of gastrointestinal cancers

2: Neurological complications of GI cancers

3: Common systemic treatment regimens for GI cancers and their neurological complications

References

Chapter 23: Neurologic complications associated with genitourinary cancer

Abstract

1: Introduction

2: Prostate cancer

3: Uterus

4: Ovarian cancer

5: Renal carcinoma

6: Germ cell testicular cancer

7: Bladder carcinoma

8: Conclusion

References

Chapter 24: Sarcoma and the nervous system

Abstract

1: Introduction

2: Primary CNS sarcomas

3: Primary sarcomas of the peripheral nervous system

4: Extra-CNS sarcoma affecting the nervous system

5: CNS metastases from extra-CNS sarcoma

6: Neurologic toxicities from sarcoma treatments

7: Conclusions

References

Chapter 25: Neurological complications of multiple myeloma

Abstract

1: Introduction

2: Central nervous system complications

3: Peripheral nervous system complications

4: Conclusion

References

Chapter 26: Neurologic complications in the treatment of childhood malignancies

Abstract

1: Introduction

2: Part I: Acute complications of cancer treatment

3: Part II: Late effects of cancer treatment

4: Conclusion

References

Section IV: Neurological complications of antineoplastic therapy

Chapter 27: Neurological complications of radiation therapy

Abstract

1: Introduction

2: Pathophysiology of neurological complications from radiation

3: Radiation-induced brain toxicity

4: Radiation-induced complications of spinal cord

5: Radiation-induced nerve injury

6: Endocrinopathy after radiation therapy

7: Cerebrovascular complications after radiation treatment

8: Radiation-induced secondary malignancy

9: Conclusion

References

Chapter 28: Neurological complications of systemic cancer and antineoplastic therapy

Abstract

1: Introduction

2: Mechanisms of neurotoxicity

3: Neurotixicity of specific agents

4: Targeted therapies

5: Biological agents

6: Chemotherapy-induced cognitive impairment

7: Conclusion

References

Chapter 29: Neurological complications of hematopoietic stem cell transplantation

Abstract

1: Introduction

2: Neurologic complications associated with conditioning regimens

3: Toxic-metabolic encephalopathy

4: Cerebrovascular complications

5: CNS infections

6: Neurologic complications associated with chronic graft versus host disease (GVHD)

7: Neurologic complications associated with immunosuppressive therapy

8: Neurocognitive dysfunction

9: Secondary malignancies

10: Conclusion

References

Chapter 30: Chemotherapy-induced peripheral neuropathy

Abstract

1: Introduction

2: Pathophysiology of CIPN

3: Clinical presentation and diagnostic evaluation of CIPN

4: Clinical management of CIPN

References

Chapter 31: Neurological complications of immunotherapy and monoclonal antibody therapy

Abstract

1: Introduction

2: Bevacizumab

3: Cetuximab and other anti-EGFR mAbs

4: Trastuzumab

5: Rituximab and other anti-CD20 mAbs

6: Dinutuximab

7: Brentuximab vedotin

8: Polatuzumab vedotin

9: Enfortumab vedotin

10: Trastuzumab emtansine

11: Blinatumomab

12: Interleukin-2 (IL2)

13: Interferon alpha

References

Chapter 32: Neurologic complications of immune modulatory therapy

Abstract

1: Introduction

2: Epidemiology

3: Headache

4: Malignant cerebral edema

5: Peripheral nervous system

6: Central nervous system

7: CAR T cell-mediated neurotoxicity (immune effector cell-associated neurotoxicity syndrome)

8: Conclusion: Diverse presentation, kinetics, importance of multidisciplinary and early treatment, consideration of re-challenge

References

Chapter 33: Neurological complications of steroids and of supportive care

Abstract

Acknowledgment

1: Introduction

2: Corticosteroids

3: Seizures

4: Vascular complications

5: Analgesics

6: Antiemetics

7: Depression

8: Summary

References

Section V: Psychiatric, pain, psychosocial, and supportive care issues

Chapter 34: Psychiatric aspects of care in the cancer patient

Abstract

1: Introduction

2: Historical background

3: Common psychological responses to cancer

4: Epidemiology of psychiatric disorders in cancer patients

5: General principles of psychiatric assessment and treatment in patients with cancer

6: Delirium

7: Adjustment disorders

8: Anxiety disorders

9: Trauma and stressor-related disorders

10: Depressive disorders

11: Suicide assessment and management in cancer patients

12: Psychiatric considerations in cancer-related fatigue

13: Cancer survivors

14: Families issues and bereavement

15: Psychological issues for staff

References

Chapter 35: Chronic cancer pain syndromes and their treatment

Abstract

1: Bone pain

2: Pain syndromes of the viscera and miscellaneous tumor-related syndromes

3: Headache and facial pain

4: Neuropathic pain involving the peripheral nervous system

5: Paraneoplastic nociceptive pain syndromes

6: Chronic pain syndromes associated with cancer therapy

7: Clinical evaluation of the patients with difficult pain

References

Further reading

Chapter 36: Psychosocial issues in cancer patients with neurological complications

Abstract

1: Introduction

2: Neurocognitive concerns

3: Psychological concerns

4: Behavioral concerns

5: Social concerns

6: Disparity concerns

7: End-of-life concerns

8: Conclusion

References

Chapter 37: Supportive care

Abstract

1: Introduction

2: Novel antiangiogenic agents

3: Conclusion

References

Index

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Tags: Herbert B Newton, Mark G Malkin, Neurological Complications, Systemic Cancer, Antineoplastic