Plant Extracts in Neurodegenerative Diseases 1st Edition by Magisetty Obulesu ISBN 9780323957625 0323957625

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ISBN 10: 0323957625
ISBN 13: 9780323957625
Author: Magisetty Obulesu

Plant Extracts in Neurodegenerative Disease examines the therapeutic efficacy of plant extracts and the lead compounds contained therein that can significantly improve symptoms of diseases of the brain. Providing insights into the protective mechanisms of these bioactive plant compounds to treat Alzheimer’s Disease, Parkinson’s Disease, motor neuron disease, and other neurodegenerative diseases, the book also discusses the pros and cons of using these types of treatments, along with perspectives to overcome current challenges. With chapters looking at individual diseases, readers will learn about studies unique to each condition, including Huntington’s Disease, spinocerebellar ataxia, SMA, ALS and prion disease.

Discusses the therapeutic efficacy of plant extracts and their lead bioactive compounds to treat neurodegenerative disease

Describes protective mechanisms, pros and cons, and future perspectives

Contains individual diseases in each chapter, including Alzheimer’s, Parkinson’s, Huntington’s, motor neuron disease, spinocerebellar ataxia, prion disease, SMA and ALS

Plant Extracts in Neurodegenerative Diseases 1st Edition Table of contents:

Chapter 1 Effect of plant extracts against Alzheimer’s disease

Introduction

Pathology

Plant extracts

Diet

Polyphenols

Flavonoids

Genistein

Icariside

Onjisaponin

Asarones

Liquiritin

Tanshinone IIA and cryptotanshinone

Ginsenoside Rg1

n-Butylidenephthalide

Green nanotechnology

Conclusions and future perspectives

Chapter 2 Potential plant extracts in the treatment of Parkinson’s disease

Introduction

Pathology

α-Synuclein

Plant extracts

Pharmacological chaperones combat Parkinson’s disease

Phytochemicals

Baicalein

Curcumin

Nanotechnology

Scutellaria pinnatifida (S. pinnatifida)

Hypericum perforatum

Mentha × piperita (peppermint)

Cyanobacteria spirulina

Omega-3 fatty acids

Conclusions and future perspectives

Chapter 3 Panoply of plant extracts in the treatment of prion diseases

Introduction

Pathology

Plants and prions

Metal dyshomeostasis

Plants

Polyphenols

Resveratrol

Curcumin

Polyphenolic metal chelators

Mediterranean diet

Lichens

Conclusions and future perspectives

Chapter 4 Efficacy of plant extracts against Friedreich’s ataxia

Introduction

Pathology

Frataxin

Iron accumulation

Iron dyshomeostasis in Friedreich’s ataxia

Plant extracts

Coenzyme Q10 and idebenone

Nuclear factor erythroid 2-related factor

Resveratrol

Antioxidants

Conclusions and future perspectives

Chapter 5 Plant extracts ameliorate Huntington’s disease symptoms

Introduction

Pathology

Free radicals

Antioxidants

Oxidative stress in Huntington’s disease

Plant extracts

Clinical trials

Cleistocalyx nervosum var. paniala

Guarana

Protective efficacy of guarana against neurodegenerative diseases

Conclusions and future perspectives

Chapter 6 Phytochemicals and their potential protective effects against spinocerebellar ataxia

Introduction

Pathology

Dendrite

Plant extracts

Ubiquitin-proteasome system and mechanism of action

Antioxidant activity

Ginkgo biloba

Bacopa monnieri

Chionanthus retusus Lindl. et Paxton (C. retusus)

Azadiradione

Conclusions and future perspectives

Chapter 7 Multifarious plant compounds and their protective efficacy in the treatment of spinal muscular atrophy

Introduction

Pathology

Nusinersen therapy

Plant extracts

Kiwi fruit

RNA-targeted therapy

Conclusions and future perspectives

Chapter 8 Improvement of amyotrophic lateral sclerosis symptoms using plant extracts

Introduction

Pathology

DNA damage

Plant extracts

Clinical trials

Mecasin

Ashwagandha

Withaferin A

Drawbacks

Polyphenols

Resveratrol

Curcumin

Conclusions and future perspectives

Chapter 9 Neuroprotective role of curcumin in amyotrophic lateral sclerosis

Introduction

Pathology

Oxidative stress

Therapy

Curcumin

Dimethoxy curcumin

Curcumin against TDP-43

Use of adjuvants

Nanotechnology

Nanocurcumin in the treatment of ALS

Conclusions and future perspectives

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Tags: Magisetty Obulesu, Plant Extracts, Neurodegenerative Diseases