Plant Extracts in Neurodegenerative Diseases 1st Edition by Magisetty Obulesu – Ebook PDF Instant Download/Delivery: 9780323957632 ,0323957633
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Product details:
ISBN 10: 0323957633
ISBN 13: 9780323957632
Author: Magisetty Obulesu
Plant Extracts in Neurodegenerative Disease examines the therapeutic efficacy of plant extracts and the lead compounds contained therein that can significantly improve symptoms of diseases of the brain. Providing insights into the protective mechanisms of these bioactive plant compounds to treat Alzheimer’s Disease, Parkinson’s Disease, motor neuron disease, and other neurodegenerative diseases, the book also discusses the pros and cons of using these types of treatments, along with perspectives to overcome current challenges. With chapters looking at individual diseases, readers will learn about studies unique to each condition, including Huntington’s Disease, spinocerebellar ataxia, SMA, ALS and prion disease.
- Discusses the therapeutic efficacy of plant extracts and their lead bioactive compounds to treat neurodegenerative disease
- Describes protective mechanisms, pros and cons, and future perspectives
- Contains individual diseases in each chapter, including Alzheimer’s, Parkinson’s, Huntington’s, motor neuron disease, spinocerebellar ataxia, prion disease, SMA and ALS
Plant Extracts in Neurodegenerative Diseases 1st Edition Table of contents:
Chapter 1: Effect of plant extracts against Alzheimer’s disease
Abstract
Introduction
Plant extracts
Polyphenols
Flavonoids
Genistein
Icariside
Onjisaponin
Asarones
Liquiritin
Tanshinone IIA and cryptotanshinone
Ginsenoside Rg1
n-Butylidenephthalide
Green nanotechnology
Conclusions and future perspectives
References
Chapter 2: Potential plant extracts in the treatment of Parkinson’s disease
Abstract
Introduction
α-Synuclein
Plant extracts
Pharmacological chaperones combat Parkinson’s disease
Phytochemicals
Baicalein
Curcumin
Nanotechnology
Scutellaria pinnatifida (S. pinnatifida)
Hypericum perforatum
Mentha × piperita (peppermint)
Cyanobacteria spirulina
Omega-3 fatty acids
Conclusions and future perspectives
References
Chapter 3: Panoply of plant extracts in the treatment of prion diseases
Abstract
Introduction
Plants and prions
Metal dyshomeostasis
Plants
Polyphenols
Resveratrol
Curcumin
Polyphenolic metal chelators
Mediterranean diet
Lichens
Conclusions and future perspectives
References
Chapter 4: Efficacy of plant extracts against Friedreich’s ataxia
Abstract
Introduction
Frataxin
Iron accumulation
Iron dyshomeostasis in Friedreich’s ataxia
Plant extracts
Coenzyme Q10 and idebenone
Nuclear factor erythroid 2-related factor
Resveratrol
Antioxidants
Conclusions and future perspectives
References
Further reading
Chapter 5: Plant extracts ameliorate Huntington’s disease symptoms
Abstract
Introduction
Pathology
Antioxidants
Oxidative stress in Huntington’s disease
Plant extracts
Clinical trials
Cleistocalyx nervosum var. paniala
Guarana
Protective efficacy of guarana against neurodegenerative diseases
Conclusions and future perspectives
References
Chapter 6: Phytochemicals and their potential protective effects against spinocerebellar ataxia
Abstract
Introduction
Dendrite
Plant extracts
Ubiquitin-proteasome system and mechanism of action
Antioxidant activity
Ginkgo biloba
Bacopa monnieri
Chionanthus retusus Lindl. et Paxton (C. retusus)
Azadiradione
Conclusions and future perspectives
References
Chapter 7: Multifarious plant compounds and their protective efficacy in the treatment of spinal muscular atrophy
Abstract
Introduction
Nusinersen therapy
Plant extracts
Kiwi fruit
RNA-targeted therapy
Conclusions and future perspectives
References
Chapter 8: Improvement of amyotrophic lateral sclerosis symptoms using plant extracts
Abstract
Introduction
DNA damage
Plant extracts
Clinical trials
Mecasin
Ashwagandha
Withaferin A
Drawbacks
Polyphenols
Resveratrol
Curcumin
Conclusions and future perspectives
References
Further reading
Chapter 9: Neuroprotective role of curcumin in amyotrophic lateral sclerosis
Abstract
Introduction
Oxidative stress
Therapy
Curcumin
Dimethoxy curcumin
Curcumin against TDP-43
Use of adjuvants
Nanotechnology
Nanocurcumin in the treatment of ALS
Conclusions and future perspectives
References
Index
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Tags: Magisetty Obulesu, Plant Extracts, Neurodegenerative Diseases