Prions and Diseases 2nd Edition by Wen Quan Zou, Pierluigi Gambetti 3031205650 9783031205651

Part I. History

1. Transmissible Spongiform Encephalopathy: From Its Beginnings to Daniel Carleton Gajdusek

Part II. General Aspects of Prions

2. The Rich Chemistry of the Copper and Zinc Sites in PrPC

3. PrP Prion Structures

4. Insoluble Cellular Prion Protein and Other Neurodegeneration-Related Protein Aggregates in the Brain of Asymptomatic Individuals

Part III. Conversion and Strain of Prions

5. Prion Conversion and Deformed Templating

6. Prion Strain Interference

7. Molecular Mechanisms Encoding Strains of Prions and Prion-Like Misfolded Proteins

8. Cofactor Involvement in Prion Propagation

9. Prion Protein Conversion and Lipids

Part IV. Environment and Transmission of Prions

10. Prions in the Environment

11. Environmentally Acquired Transmissible Spongiform Encephalopathy

12. Risk of Transmission of Creutzfeldt–Jakob Disease by Blood Transfusion

13. Species Barriers in Prion Disease

Part V. Modelling of Prions

14. Modeling the Cell Biology of Prions

15. Transgenic Mice Modelling in Prion Diseases

16. Stem Cell Models in Prion Research

17. Drosophila Models of Prion Diseases

Part VI. Human Prion Diseases and Other Pathologies

18. Human Sporadic Prion Diseases

19. Genetics of Prion Disease

20. Glycoform-Selective Prions in Sporadic and Genetic Variably Protease-Sensitive Prionopathies

21. The Spectrum of Tau Pathology in Human Prion Disease

22. Prion Protein Complex with mGluR5 Mediates Amyloid-ß Synaptic Loss in Alzheimer’s Disease

23. Prion and Cancers

24. Protective Role of Cellular Prion Protein in Tissues Ischemic/Reperfusion Injury

Part VII. Animal Prion Diseases

25. Bovine Spongiform Encephalopathy

26. Classical and Atypical Scrapie in Sheep and Goats

27. Research Models for Studying Chronic Wasting Disease

Part VIII. Yeast Prions

28. Introduction to Yeast and Fungal Prions

29. Yeast Prions Are Folded, In-Register Parallel Amyloids Subject to Multiple Anti-prion Systems

Part IX. Diagnosis and Human Prion Surveillance

30. Real-Time Quaking-Induced Conversion (QuIC) Assays for the Detection and Diagnosis of Human Prion Diseases

31. Protein Misfolding Cyclic Amplification

32. Seeding Activity of Skin Misfolded Proteins as a Biomarker in Prion and Prion-Like Diseases

33. Diagnosis of Prion Disease: Conventional Approaches

34. Human Prion Disease Surveillance

Part X. Treatment

35. Overview on Treatment of Prion Diseases and Decontamination of Prions

36. Gene Therapy Strategies for Prophylactic and Therapeutic Treatments of Human Prion Diseases

37. Immunomodulation

Back Matter