Protein Degradation with New Chemical Modalities: Successful Strategies in Drug Discovery and Chemical Biology 1st Edition by Craig Crews, Hilmar Weinmann 9781839160776 1839160772

Protein Degradation with New Chemical Modalities: Successful Strategies in Drug Discovery and Chemical Biology 1st Edition Craig Crews & Hilmar Weinmann – Ebook Instant Download/Delivery ISBN(s): 9781788016865, 9781839160691, 9781839160776, 1788016866, 1839160691, 1839160772

Product details:

• ISBN 10: 1839160772
• ISBN 13: 9781839160776
• Author: Craig Crews, Hilmar Weinmann

Targeting protein degradation using small molecules is one of the most exciting small-molecule therapeutic strategies in decades and a rapidly growing area of research. In particular, the development of proteolysis targeting chimera (PROTACs) as potential drugs capable of recruiting target proteins to the cellular quality control machinery for elimination has opened new avenues to address traditionally ‘difficult to target’ proteins. This book provides a comprehensive overview from the leading academic and industrial experts on recent developments, scope and limitations in this dynamically growing research area; an ideal reference work for researchers in drug discovery and chemical biology as well as advanced students.

Table contents:

Chapter 1 PROTAC-mediated Target Degradation: A Paradigm Changer in Drug Discovery?

Chapter 2 Structural and Biophysical Principles of Degrader Ternary Complexes

Chapter 3 Immediate and Selective Control of Protein Abundance Using the dTAG System

Chapter 4 Developing Pharmacokinetic/Pharmacodynamic Relationships With PROTACs

Chapter 5 New Activities of CELMoDs, Cereblon E3 Ligase-modulating Drugs

Chapter 6 Structure-based PROTAC Design

Chapter 7 Plate-based High-throughput Cellular Degradation Assays to Identify PROTAC Molecules and Protein Degraders

Chapter 8 PROTAC Targeting BTK for the Treatment of Ibrutinib-resistant B-cell Malignancies

Chapter 9 An Efficient Approach Toward Drugging Undruggable Targets

Chapter 10 E3-mediated Ubiquitin and Ubiquitin-like Protein Ligation: Mechanisms and Chemical Probes

Chapter 11 Plant E3 Ligases as Versatile Tools for Novel Drug Development and Plant Bioengineering

Chapter 12 Deubiquitinase Inhibitors: An Emerging Therapeutic Class

Chapter 13 Targeting Translation Regulation for the Development of Novel Drugs

Chapter 14 Classes, Modes of Action and Selection of New Modalities in Drug Discovery

Chapter 15 Small-molecule Targeted Degradation of RNA

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