Regenerative Nephrology 2nd Edition by Michael Goligorsky 0128233184 9780128233184

Regenerative Nephrology 2nd Edition by Michael S. Goligorsky – Ebook PDF Instant Download/Delivery: 0128233184, 9780128233184

Full download Regenerative Nephrology 2nd Edition after payment

Product details:

ISBN 10: 0128233184
ISBN 13: 9780128233184
Author: Michael S. Goligorsky

Since the publication of the first edition of this book in 2010, an explosion of spectacular discoveries in the field of regeneration has compelled the current revisit of the field of Regenerative Nephrology. This second edition features subjects as diverse as age and gender influencing regenerative processes; mechanisms and pathways of premature cell senescence affecting kidney regeneration; the ways intrinsic regenerative processes can become subverted by noxious stressors eventuating in disease progression; novel mechanistic and engineering efforts to recreate functional kidney or its component parts; cell reprogramming and reconditioning as emerging tools of future regenerative efforts; and effects of various biologicals on kidney regeneration. These newer additions to the armamentarium of Regenerative Medicine and Nephrology have become an integral part of the second edition of the book. Cutting-edge investigations are summarized by the constellation of the most experienced contributing authors coming together from around the world under the umbrella of the second edition.

Regenerative Nephrology 2nd Table of contents:

Chapter 1 Nephrogenesis in health and disease
Introduction
Experimental models
Developmental events preceding kidney development
Cell populations in the metanephric kidney
Molecular control of kidney development: The ureteric bud/collecting duct lineage
Molecular control of kidney development: The metanephric mesenchyme/nephron lineage
Urinary tract development
Abnormal development of the renal tract
Models of renal agenesis
Models of renal dysplasia
Models of renal hypoplasia
Urinary tract malformations
Summary
References
Chapter 2 Renal organogenesis in the lymph node microenvironment
Introduction
Generation of tissue-engineered kidneys
Traditional transplantation sites for experimental kidney tissue engineering
The lymph node microenvironment as an alternative site for kidney tissue engineering
Engraftment of mouse and human fetal primary tissues in the lymph node
Engraftment of isolated or artificially created nephron progenitors in the lymph node
Lymphatic cues supporting kidney organogenesis
Conclusions
References
Chapter 3 In vivo clonal analysis and the kidney: Implications to regenerative nephrology
Introduction
Principles of in vivo lineage tracing
Lineage tracing for elucidation of critical steps in nephrogenesis
Postnatal lineage tracing for elucidation of homeostatic and damage-response mechanisms in the kidney
Lineage tracing in the adult kidney
Multicolored transgenic mice
Lineage tracing in the service of renal regenerative medicine
Consideration and limitations
Summary
References
Chapter 4 Nephrogenesis in malnutrition
Introduction
Kidney development and nephrogenesis overview
Impaired nephrogenesis during maternal malnourishment
Effects of macronutrient and micronutrient deficiency on kidney development
Protein
Lipids, fats, and fatty acids
Vitamin A
Vitamin B
Vitamin C
Vitamin D
Vitamin E
Zinc
Iron
Other minerals
Conclusion
References
Chapter 5 Endogenous antiinflammatory and proresolving lipid mediators in renal disease
Introduction
Lipid mediators of inflammation
Receptor activation by SPMs
Renal inflammation, resolution, and fibrosis
From biology to therapy?
Conclusion
References
Chapter 6 T cells in kidney injury and regeneration
Introduction
Conventional T cells and resident kidney T cells
Evidence of T cells in AKI and allograft kidney rejection
T cell subpopulations in mouse kidney IRI
CD4+ and CD8+ T cells in AKI
Mechanisms of T cells in kidney AKI
Antigen-independent versus -dependent mechanisms in kidney IRI
IFN-γ and NGAL in AKI
Th1/Th2 and STAT4/STAT6 pathways in kidney IRI
IL-17A and Th17 in AKI
Resident innate-like T cells in kidney IRI: NKT cells and innate lymphoid cells (ILCs, including NK cells, γδ T cells, MAIT cells, and double negative (DN) T cells)
Invariant natural killer T (iNKT) and type II NKT cells in kidney IRI
Double negative (DN) αβ TCR T cells in AKI and kidney repair
Innate lymphoid cells (ILCs)
Mucosal-associated invariant T (MAIT) cells
T cells in the cholinergic antiinflammatory pathway in AKI
γδ T cells in AKI and kidney fibrosis
Regulatory T cells in AKI, kidney repair, and regeneration
Treg immunosuppressive mechanisms
Tregs in AKI
Tregs in kidney ischemic preconditioning (IPC)
Tregs in nephrotoxic AKI
Tregs in septic AKI
Tregs in recovery/repair from AKI
Treg therapeutic approaches for AKI
Tregs in kidney transplant
CD4+  IL-22+ cells in kidney regeneration/repair
Conclusion
References
Chapter 7 Monocytes and dendritic cells in injury and regeneration
Models of kidney injury
Injury
Tubular epithelial cells
Neutrophils
Dendritic cells
Macrophages
Eosinophils
Recovery
Tubular epithelial cells
Macrophages
Myeloid-derived suppressor cells
Failure to recover
Macrophages
Current therapies
References
Chapter 8 Mast cells in kidney regeneration
Introduction
Basic biology of mast cells
Origin, tissue distribution and heterogeneity of mast cells
Mast cell mediators
Receptors expressed by mast cells
Model systems to study mast cell functions
Positive roles of mast cells in inflammation
Mast cells as regulators of immune and inflammatory reactions
Inflammation and kidney diseases: A regenerative perspective
MC in kidney disease
Localization of mast cells in normal and pathologic kidneys
MC in human renal diseases
Insights from animal models
Positive actions of mast cell mediators in kidney disease
Fibrinolytic system
Heparin
MC proteases
Matrix metalloproteinases
Histamine
Immunoregulatory properties of mast cells
Growth factors
Lipid derived mediators
Concluding remarks
References
Chapter 9 Regeneration and replacement of endothelial cells and renal vascular repair
Introduction
Endothelial impairment in acute and chronic kidney injury
Progenitor cells for repairing resident vascular endothelium
Overview of cells that repair or regenerate vascular endothelium
Historical context for defining “endothelial progenitor cells”
Myeloid angiogenic cells (MACs)
Endothelial colony-forming cells (ECFCs)
Evidence for MAC and ECFC in acute and chronic kidney disease
Endothelial colony-forming cells in kidney
Hypothesis: Low ECFC activity and impaired MAC activity contribute to disease progression
Potential therapeutic benefit of PAC or ECFC
Concluding remarks, future directions
References
Chapter 10 Stem cells in regenerative processes: Induced pluripotent stem cells
Introduction
iPSCs
Kidney development
Directed differentiation into kidney lineages
Expansion culture of kidney progenitors
Cell therapy
Kidney reconstruction
Disease modeling
Hurdles to overcome
Conclusions
References
Chapter 11 Nephroprotective effect of urine-derived stem cells for renal injury
Introduction
Origin of urine-derived stem cells
Treatment of acute renal insufficiency
Treatment of chronic renal failure
Diabetic nephropathy models
Gentamicin + ischemia model
Aging-related CRF
Future directions
References
Chapter 12 Amniotic stem cells and their exosomes
Introduction
The amniotic stem cell
The origin of amnion and amniotic stem cells
Amniotic epithelial cells
Amniotic mesenchymal stem cells
Regenerative medicine with amniotic stem cells
Amniotic stem cells ameliorate renal injury and accelerate renal repair
Homing and differentiation of exogenous amniotic stem cells
Paracrine and endocrine mechanism of exogenous amniotic stem cells
Amniotic stem cell-derived exosomes and renal injury
Introduction of exosomes
Amniotic epithelial cell-derived exosomes and acute kidney injury
Amniotic mesenchymal stem cell-derived exosomes and kidney injury
Clinical trials for amniotic stem cells in renal injury
Conclusions
References
Chapter 13 Regenerative potential of stem-cell-derived extracellular vesicles
Introduction
Classification of EVs and their biogenesis
Contents of EVs and their mechanism of action
Paracrine action of stem-cell-derived EVs
EVs in the treatment of experimental AKI
Ischemia-reperfusion injury
Drug-induced AKI
EVs in the treatment of experimental CKD
Unilateral ureter obstruction
Subtotal nephrectomy
Diabetic nephropathy
References
Chapter 14 Stem cell therapies in diabetes
Introduction
Islet cell transplantation
Mesenchymal stem cells
Human pluripotent stem cells
Generation of clinical-grade hPSCs
Differentiation of hPSCs in vitro
Generation of kidney cells from hPSCs
Generation of pancreatic β cells from hPSCs
Enrichment of differentiated cells derived from hPSCs
Scalable manufacturing of differentiated cells derived from hPSCs
Clinical applications of hPSCs
Protection from immune rejection
Encapsulation
Autologous transplantation
Generation of universal or hypoimmunogenic hiPSCs
References
Chapter 15 Progression of kidney disease as a maladaptive response to injury
Mitochondria
Mitochondrial fusion and fission
Mitochondrial biogenesis
Endoplasmic reticulum (ER) stress
ER stress sensor
Maladaptive UPR response in CKD
Crosstalk between ER and mitochondria in maladaptive response in kidney injury
Lysosomes and autophagy
Conclusion
References

People also search for Regenerative Nephrology 2nd:

regenerative nephrology textbook

kidney regeneration research

stem cells in nephrology

renal tissue engineering

advances in kidney disease treatment

Tags: Regenerative, Nephrology, Michael Goligorsky,