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Systems Biology of Cell Signaling Recurring Themes and Quantitative Models 1st Edition by James Ferrell ISBN 9781000430783 1000430782

Name: Systems Biology of Cell Signaling Recurring Themes and Quantitative Models 1st Edition by James Ferrell ISBN 9781000430783 1000430782
SKU: EB-35372126
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Systems Biology of Cell Signaling Recurring Themes and Quantitative Models 1st Edition James E. Ferrell Digital Instant Download

Author(s): James E. Ferrell, Jr.

ISBN(s): 9780367643836, 9780815346036, 9781003124269, 0367643839, 0815346034, 1003124267, 2021007837, 2021007838

Edition: 1

File Details: EPUB, 15.75 MB

Year: 2021

Language: English

SKU: EB-35372126 Category: Biology and other natural sciences Tags: James E. Ferrell, Jr.

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Systems Biology of Cell Signaling Recurring Themes and Quantitative Models 1st Edition by James Ferrell – Ebook PDF Instant Download/Delivery: 9781000430783 ,1000430782
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ISBN 10: 1000430782
ISBN 13: 9781000430783
Author: James Ferrell

How can we understand the complexity of genes, RNAs, and proteins and the associated regulatory networks? One approach is to look for recurring types of dynamical behavior. Mathematical models prove to be useful, especially models coming from theories of biochemical reactions such as ordinary differential equation models. Clever, careful experiments test these models and their basis in specific theories. This textbook aims to provide advanced students with the tools and insights needed to carry out studies of signal transduction drawing on modeling, theory, and experimentation. Early chapters summarize the basic building blocks of signaling systems: binding/dissociation, synthesis/destruction, and activation/inactivation. Subsequent chapters introduce various basic circuit devices: amplifiers, stabilizers, pulse generators, switches, stochastic spike generators, and oscillators. All chapters consistently use approaches and concepts from chemical kinetics and nonlinear dynamics, including rate-balance analysis, phase plane analysis, nullclines, linear stability analysis, stable nodes, saddles, unstable nodes, stable and unstable spirals, and bifurcations. This textbook seeks to provide quantitatively inclined biologists and biologically inclined physicists with the tools and insights needed to apply modeling and theory to interesting biological processes. Key Features: Full-color illustration program with diagrams to help illuminate the concepts Enables the reader to apply modeling and theory to the biological processes Further Reading for each chapter High-quality figures available for instructors to download

Systems Biology of Cell Signaling Recurring Themes and Quantitative Models 1st Edition Table of contents:

Chapter 1: Introduction

Chapter 2: Receptors 1: Monomeric Receptors and Ligands

Chapter 3: Receptors 2: Multimeric Receptors and Cooperativity

Chapter 4: Downstream Signaling 1: Stoichiometric Regulation

Chapter 5: Downstream Signaling 2: Covalent Modification

Chapter 6: Downstream Signaling 3: Regulated Production or Destruction

Chapter 7: Cascades and Amplification

Chapter 8: Bistability 1: Systems with One Time-Dependent Variable

Chapter 9: Bistability 2: Systems with Two Time-Dependent Variables

Chapter 10: Transcritical Bifurcations in Phase Separation and Infectious Disease

Chapter 11: Negative Feedback 1: Stability and Speed