The Detection of Biomarkers Past Present, and the Future Prospects 1st Edition by Sibel Ozkan, Nurgul Bakirhan, Fariba Mollarasouli 0128228598 9780128228593

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ISBN 10: 0128228598

ISBN 13: 9780128228593

Author: Sibel A. Ozkan, Nurgul K. Bakirhan, Fariba Mollarasouli

Reliable, precise and accurate detection and analysis of biomarkers remains a significant challenge for clinical researchers. Methods for the detection of biomarkers are rather complex, requiring pre-treatment steps before analysis can take place. Moreover, comparing various biomarker assays and tracing research progress in this area systematically is a challenge for researchers. The Detection of Biomarkers presents developments in biomarker detection, including methods tools and strategies, biosensor design, materials, and applications. The book presents methods, materials and procedures that are simple, precise, sensitive, selective, fast and economical, and therefore highly practical for use in clinical research scenarios. This volume situates biomarker detection in its research context and sets out future prospects for the area. Its 20 chapters offer a comprehensive coverage of biomarkers, including progress on nanotechnology, biosensor types, synthesis, immobilization, and applications in various fields. The book also demonstrates, for students, how to synthesize and immobilize biosensors for biomarker assay. It offers researchers real alternative and innovative ways to think about the field of biomarker detection, increasing the reliability, precision and accuracy of biomarker detection.

The Detection of Biomarkers Past Present and the Future Prospects 1st Table of contents:

Chapter 1. Introduction to biomarkers

Abstract

1.1 Introduction

1.2 Classification of biomarkers

1.3 Biomarker discovery and diagnosis techniques and strategies

1.4 Biomarker validation

1.5 Biological matrices used for detection

1.6 Applications of biomarkers in medicine

1.7 Future prospects

Acknowledgement

References

Chapter 2. Low-molecular-weight biomarkers: types and detection strategies

Abstract

2.1 Introduction

2.2 Type of low-molecular-weight biomarkers

2.3 Low-molecular-weight detection strategies

2.4 Bioapplications of low-molecular-weight detection

2.5 Conclusion

References

Chapter 3. Circulating miRNAs as biomarkers for noninvasive cancer diagnosis

Abstract

3.1 Introduction

3.2 An overview of miRNAs

3.3 Definition of biosensors

3.4 Optical biosensors

3.5 Colorimetric biosensors

3.6 Fluorescence-based biosensors

3.7 Chemiluminescence- and electrochemiluminescent-based biosensors

3.8 Surface plasmon resonance-based biosensors

3.9 Electrochemical biosensors

3.10 Future perspectives

Acknowledgments

References

Chapter 4. Cardiac biomarkers: definition, detection, diagnostic use, and efficiency

Abstract

4.1 Cardiac biomarkers of the acute coronary syndrome

4.2 Biomarkers of cardiac failure

4.3 Biomarkers of coronary heart disease

4.4 Conclusion

References

Chapter 5. Proteomic-based identification of novel biomarkers

Abstract

5.1 Introduction

5.2 Designing a biomarker discovery study

5.3 Methodologies for proteomic-based biomarker discovery studies

5.4 The current state of proteomic-based biomarkers

5.5 Clinical biomarkers discovered by proteomic approaches

5.6 Limitations

5.7 Future perspectives

References

Chapter 6. Metabolomics tools for biomarker discovery: applications in chronic kidney disease

Abstract

6.1 Introduction

6.2 Metabolomics tools for the discovery of novel renal disease biomarkers

References

Chapter 7. Electronic devices for biomarker monitoring

Abstract

7.1 Introduction

7.2 Biomarkers

7.3 Sensing electronic devices: transistors

7.4 Conclusion and perspectives

References

Chapter 8. Novel advances in nanomaterial-based electrochemical sensing of the biomarker

Abstract

8.1 Introduction

8.2 Classification of biomarkers

8.3 Various nanomaterials as signal amplification

8.4 The novel advance of immobilization strategies for biomarkers

8.5 Trends research on electrochemical nano-biosensing of the biomarkers

8.6 Conclusion and future perspectives

References

Chapter 9. Carbon nanomaterials-based electrochemical cancer biomarkers biosensors

Abstract

9.1 General concepts

9.2 Carbon nanostructures-based electrochemical (bio)sensors for the quantification of cancer biomarkers

9.3 Conclusions and perspectives

Acknowledgments

References

Chapter 10. Optical nanosensor based on surface-enhanced Raman spectroscopy for biomedical and biomarker detection applications

Abstract

10.1 Introduction

10.2 Raman spectroscopy techniques for biomedical applications

10.3 Surface-enhanced Raman spectroscopy-based applications in biomarkers

10.4 Surface-enhanced Raman spectroscopy applications in bioimaging

10.5 Raman activated cell sorting

10.6 Surface-enhanced Raman spectroscopy-based microchip system

10.7 Surface-enhanced Raman spectroscopy mapping

10.8 Conclusions and future prospects

References

Chapter 11. Optical smartphone-based sensing: diagnostic of biomarkers

Abstract

11.1 Introduction

11.2 Optical smartphone-based biosensors for the detection of biomarkers

11.3 Summary and future perspectives

Acknowledgments

References

Chapter 12. Design of immunosensors for rapid and sensitive detection of biomarkers

Abstract

12.1 Immunosensor

12.2 Biomarkers and their classification

12.3 Antibodies and their immobilization methods

12.4 Immunosensor formats

12.5 Applications of nanomaterials to amplify the analytical signal of immunosensors

12.6 Transducers used for immunosensors

12.7 Multiplexed assay–based immunosensors for biomarkers detection

12.8 Conclusions and future outlook

Acknowledgments

References

Chapter 13. Recent advances in immunosensors for healthcare

Abstract

13.1 Introduction

13.2 Immunosensors for healthcare

13.3 Summary and outlooks

References

Chapter 14. Impedimetric immunosensors for detection of biomarkers

Abstract

14.1 Introduction

14.2 Conclusion and future remarks

References

Chapter 15. Conducting polymers—versatile tools in analytical systems for the determination of biomarkers and biologically active compounds

Abstract

15.1 Introduction

15.2 Conclusions

Funding

Conflicts of interest

References

Chapter 16. Molecularly imprinted biosensors for sensitive detection of biomarkers

Abstract

16.1 Introduction

16.2 Biomarkers

16.3 Molecularly imprinting technology

16.4 Surface imprinting

16.5 Electrochemical transduction

16.6 Voltammetry/amperometry

16.7 Potentiometry

16.8 Capacitance/impedance

16.9 Optical sensors

16.10 Piezoelectric sensors

16.11 Conclusion

References

Chapter 17. Microfluidics technology: past, present, and future prospects for biomarker diagnostics

Abstract

17.1 General introduction

17.2 Type of microfluidics system

17.3 Application of microfluidic system

17.4 Future and perspectives

References

Chapter 18. Wearable biosensors for monitoring of disease-related biomarkers

Abstract

18.1 Introduction

18.2 Wearable (bio)devices for monitoring of disease biomarkers

18.3 Wearable optical (bio)sensors

18.4 Wearable electrochemical biosensors

18.5 Opportunities, challenges, concerns, and future prospects

Acknowledgments

References

Chapter 19. Nanomachines and nanorobotics: improving cancer diagnosis and therapy

Abstract

19.1 Introduction

19.2 Nanomachines at a glance

19.3 Nanodevices in cancer diagnosis and imaging

19.4 Nanomachines in active cancer drugs delivery

19.5 Nanomachines and nanorobots for cancer theragnostic

19.6 Nanosurgery

19.7 Conclusion and future prospects

Acknowledgments

References

Chapter 20. Analytical perspective on biomarkers research: from untargeted to targeted metabolomics

Abstract

20.1 Introduction

20.2 Krebs cycle targeted pathway analysis

20.3 Sulfur pathway

20.4 Phosphonucleotides

20.5 Validation of targeted metabolomic analysis

20.6 Conclusion

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Sibel Ozkan,Nurgul Bakirhan,Fariba Mollarasouli,Detection,Biomarkers